Blog
About

  • Record: found
  • Abstract: found
  • Article: found
Is Open Access

CD11b and TLR4 in human neutrophil priming by endotoxins from Escherichia coli

, 1 , 1 , 1 , 1

Critical Care

BioMed Central

Sepsis 2013

5-6 November 2013

Read this article at

Bookmark
      There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

      Related collections

      Most cited references 6

      • Record: found
      • Abstract: found
      • Article: not found

      Lipopolysaccharide and ceramide docking to CD14 provokes ligand-specific receptor clustering in rafts.

      The glycosylphosphatidylinositol-anchored receptor CD14 plays a major role in the inflammatory response of monocytes to lipopolysaccharide. Here, we describe that ceramide, a constituent of atherogenic lipoproteins, binds to CD14 and induces clustering of CD14 to co-receptors in rafts. In resting cells, CD14 was associated with CD55, the Fcgamma-receptors CD32 and CD64 and the pentaspan CD47. Ceramide further recruited the complement receptor 3 (CD11b/CD18) and CD36 into proximity of CD14. Lipopolysaccharide, in addition, induced co-clustering with Toll-like receptor 4, Fcgamma-RIIIa (CD16a) and the tetraspanin CD81 while CD47 was dissociated. The different receptor complexes may be linked to ligand-specific cellular responses initiated by CD14.
        Bookmark
        • Record: found
        • Abstract: found
        • Article: not found

        CD14 signalling in lipid rafts: new ligands and co-receptors.

        Lipid rafts on monocytes/macrophages provide a dynamic microenvironment for an integrated lipopolysaccharide receptor (CD14)-dependent clustering of a set of receptors involved in innate immunity and clearance of atherogenic lipoproteins. The purpose of this review is to summarize the recent advances in our understanding of CD14-dependent receptor clustering and its relevance in atherogenesis. Upon binding of various ligands, CD14 as a multiligand pattern recognition receptor induces specific coassembly of additional receptors present on circulating monocytes. The composition of the receptor cluster and thus the associated signalling pathways defines a ligand specific cellular response, linking endogenous and exogenous host defense to a common recognition platform in rafts.
          Bookmark
          • Record: found
          • Abstract: not found
          • Article: not found

          Integrins limit the Toll.

            Bookmark

            Author and article information

            Affiliations
            [1 ]Institute of Basic Biological Problems, Pushchino, Moscow Region, Russia
            Conference
            Crit Care
            Crit Care
            Critical Care
            BioMed Central
            1364-8535
            1466-609X
            2013
            5 November 2013
            : 17
            : Suppl 4
            : P75
            3952745
            cc12974
            10.1186/cc12974
            Copyright © 2013 Prokhorenko et al.; licensee BioMed Central Ltd.

            This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

            Sepsis 2013
            Rio de Janeiro, Brazil
            5-6 November 2013
            Categories
            Poster Presentation

            Emergency medicine & Trauma

            Comments

            Comment on this article