Autophagy is activated in compression-induced cell degeneration and is mediated by reactive oxygen species in nucleus pulposus cells exposed to compression.

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Abstract

To determine whether autophagy contributes to the pathogenesis of degenerative disc disease (DDD) or retards the intervertebral disc (IVD) degeneration, and investigate the possible relationship between compression-induced autophagy and intracellular reactive oxygen species (ROS) in nucleus pulposus (NP) cells in vitro.

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Journal

Journal ID (iso-abbrev): Osteoarthr. Cartil.

Title: Osteoarthritis and cartilage

ISSN (Electronic): 1522-9653

ISSN (Print): 1063-4584

Publication date (Electronic): Dec 2013

Volume: 21

Issue: 12

Affiliations

[1 ] Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Article

Publisher Item ID: S1063-4584(13)00973-4

DOI: 10.1016/j.joca.2013.10.002

PubMed ID: 24120490

SO-VID: 290f0e7c-eb1d-4fdf-aae2-0e545561ba53

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Keywords: Apoptosis,Autophagy,Compression,Intervertebral disc,Nucleus pulposus cells,Reactive oxygen species

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Keywords: Apoptosis, Autophagy, Compression, Intervertebral disc, Nucleus pulposus cells, Reactive oxygen species

Autophagy is activated in compression-induced cell degeneration and is mediated by reactive oxygen species in nucleus pulposus cells exposed to compression.

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