Phosphorus overload and PTH induce aortic expression of Runx2 in experimental uraemia.

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Abstract

Vascular calcification (VC) is commonly seen in patients with chronic kidney disease (CKD). Elevated levels of phosphate and parathormone (PTH) are considered nontraditional risk factors for VC. It has been shown that, in vitro, phosphate transforms vascular smooth muscle cells (VSMCs) into calcifying cells, evidenced by upregulated expression of runt-related transcription factor 2 (Runx2), whereas PTH is protective against VC. In addition, Runx2 has been detected in calcified arteries of CKD patients. However, the in vivo effect of phosphate and PTH on Runx2 expression remains unknown.

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Journal

Journal ID (iso-abbrev): Nephrol Dial Transplant

Title: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

Publisher: Oxford University Press (OUP)

ISSN (Electronic): 1460-2385

ISSN (Print): 0931-0509

Publication date (Electronic): May 2009

Volume: 24

Issue: 5

Affiliations

[1 ] Nephrology Division, Department of Internal Medicine, University of São Paulo, São Paulo, Brazil.

Article

Publisher Item ID: gfn686

DOI: 10.1093/ndt/gfn686

PubMed ID: 19075196

SO-VID: 2930b084-af69-4045-bcf4-f5dbe20d60bb

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