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      Extent of Increase in Intracellular Calcium Concentration in Electrically Stimulated Chick Embryo Heart Cells Does Not Depend on Resting Intracellular Calcium Concentration

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          Abstract

          Using Fura-2 digital imaging microscopy, we found two cell populations in chick embryo heart with different resting intracellular calcium concentration ([Ca<sup>2+</sup>]<sub>i</sub>). Electrical stimulation of the cells led to the same increase in [Ca<sup>2+</sup>]<sub>i</sub> in both cell types, e.g. from 118 ± 24 n M up to a peak of 243 ± 67 n M (SD, n = 18) and from 44 ± 15 n M up to a peak of 135 ± 59n M(SD, n = 13) in cells with high and low resting [Ca<sup>2+</sup>]<sub>i,</sub> respectively. All the cells showed the same rate of decline in [Ca<sup>2+</sup>]<sub>i.</sub> Due to synchronic stimulation and contraction, this method is suitable to measure [Ca<sup>2+</sup>]<sub>i</sub> transients at a high time resolution in individual cells.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1993
          1993
          14 November 2008
          : 83
          : 1-2
          : 55-60
          Affiliations
          aInstitut für Ernährungswissenschaft; bStrahlenzentrum, und cInstitut für Biochemie und Endokrinologie, Justus-Liebig-Universität Giessen, BRD
          Article
          175948 Cardiology 1993;83:55–60
          10.1159/000175948
          8261488
          © 1993 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 6
          Categories
          General Cardiology, Basic Research

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