Changes in Mitochondrial Morphology and Bioenergetics in Human Lymphoblastoid Cells With Four Novel OPA1 Mutations.

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Mutations in the optic atrophy 1 gene (OPA1) have been reported in patients with autosomal dominant optic atrophy (ADOA). OPA1 plays important roles in mitochondrial dynamics and cell apoptosis. The link between OPA1 mutations and changes in bioenergetics is still not fully resolved. The aim of this study was to investigate the effects of OPA1 mutations on the mitochondrial tubular network and bioenergetics.

Related collections

Author and article information

Journal

Journal ID (iso-abbrev): Invest. Ophthalmol. Vis. Sci.

Title: Investigative ophthalmology & visual science

Publisher: Association for Research in Vision and Ophthalmology (ARVO)

ISSN (Electronic): 1552-5783

ISSN (Print): 0146-0404

Publication date (Electronic): Apr 2015

Volume: 56

Issue: 4

Affiliations

[1 ] School of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.

[2 ] Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan 3School of Medicine, National Yang-Ming University, Taipei, Taiwan.

[3 ] School of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan 4Graduate Institute of Medical Science, College of Medicine, Taipei Medical University, Taipei, Taiwan.

Article

Publisher Item ID: iovs.14-16288

DOI: 10.1167/iovs.14-16288

PubMed ID: 25744979

SO-VID: 295a11d8-e733-44cb-a249-849b4cd3624f

History

Data availability:

Comments

Comment on this article

scite_

Cited by 15

See all cited by