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      Weight and Growth Requirements for Menarche in Teenage Girls with Eating Disorders, Weight Loss and Primary Amenorrhea

      Hormone Research in Paediatrics

      S. Karger AG

      Primary amenorrhea, Puberty, Anorexia nervosa, Eating disorder, Menarche

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          Background/Aim: To investigate weight and growth requirements for menarche in girls with eating disorders (ED), weight loss and primary amenorrhea. Methods: Growth charts from school health services and measurements of weight and stature throughout treatment were obtained for 47 such girls. Results: Weight loss started at an age of 12.4 ± 1.6 years from a top weight of 41.7 ± 7.1 kg. Approximately a year later they had lost 5.1 ± 4.3 kg and grown only 2.8 ± 3.5 cm. Following treatment and weight gain, growth accelerated and the girls reached a peak growth velocity of 4.3 ± 2.6 cm/year 2 years before menarche which occurred at an age of 15.5 ± 1.6 years at a weight of 52.2 ± 5.3 kg. Menarche occurred within a wide range of weights but could be predicted by a linear regression on prepubertal weight (R<sup>2</sup> = 0.39; p < 0.001). Conclusions: Following treatment, girls with ED and primary amenorrhea progress through puberty at a slowed rate. The weight required for menarche can be predicted by the prepubertal weight which may represent the individual’s normal growth track unaffected by the ED.

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          Most cited references 10

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          Plasma Leptin Levels in Healthy Children and Adolescents: Dependence on Body Mass Index, Body Fat Mass, Gender, Pubertal Stage, and Testosterone

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                Author and article information

                Horm Res Paediatr
                Hormone Research in Paediatrics
                S. Karger AG
                January 2008
                08 January 2008
                : 69
                : 3
                : 146-151
                Department of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden
                112587 Horm Res 2008;69:146–151
                © 2008 S. Karger AG, Basel

                Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

                Page count
                Figures: 3, Tables: 2, References: 22, Pages: 6
                Original Paper


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