Evidence for central hypercortisolism and elevated blood pressure in adolescent offspring of mothers with pre-eclampsia.

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Abstract

Maternal total and free cortisol concentrations are reduced in pre-eclampsia (PE) and gestational hypertension (GH). However, the effect of this on the hypothalamic-pituitary-adrenal (HPA) axis function in the offspring is unknown. We examined the basal HPA axis activity in adolescent offspring of mothers with pre-pregnancy hypertension/GH/PE.

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Journal

Journal ID (iso-abbrev): Clin. Endocrinol. (Oxf)

Title: Clinical endocrinology

Publisher: Wiley

ISSN (Electronic): 1365-2265

ISSN (Print): 0300-0664

Publication date (Electronic): Oct 2016

Volume: 85

Issue: 4

Affiliations

[1 ] Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA, Australia. david.henley@uwa.edu.au.

[2 ] School of Medicine and Pharmacology, The University of Western Australia, Crawley, WA, Australia. david.henley@uwa.edu.au.

[3 ] Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA, Australia.

[4 ] School of Women's and Infants' Health, The University of Western Australia, Crawley, WA, Australia.

[5 ] Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.

[6 ] Endocrine and Metabolic Unit, Royal Adelaide Hospital, Adelaide, SA, Australia.

[7 ] School of Medicine, University of Adelaide, Adelaide, SA, Australia.

Article

DOI: 10.1111/cen.13092

PubMed ID: 27144974

SO-VID: 29676007-a03e-4524-b67e-ba755bdb341d

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