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      Genetic analysis of simulated oligogenic traits in nuclear and extended pedigrees: summary of GAW10 contributions.

      Genetic Epidemiology
      Computer Simulation, Female, Genetic Linkage, Humans, Male, Models, Genetic, Nuclear Family, Pedigree, Phenotype, Predictive Value of Tests, Quantitative Trait, Heritable

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          Abstract

          Participants of GAW10 had available simulated data on phenotypic and marker data for 200 replicates of each of two different collections of pedigrees. The simulated phenotype was multivariate and oligogenic, and included a number of complexities. Participants took widely different approaches to analysis. We compare their results to identify analysis approaches and use of the data that had the greatest impact on the conclusions, accuracy of estimates, and power to identify genetic factors.

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          Author and article information

          Journal
          9433569
          10.1002/(SICI)1098-2272(1997)14:6<719::AID-GEPI28>3.0.CO;2-S

          Chemistry
          Computer Simulation,Female,Genetic Linkage,Humans,Male,Models, Genetic,Nuclear Family,Pedigree,Phenotype,Predictive Value of Tests,Quantitative Trait, Heritable

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