Relationship of Parathyroid Adenoma Volume and Biochemical Function

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Abstract

We retrospectively studied data of 24 patients with surgically proven hyperparathyroidism to determine whether biochemical function correlated with the calculated volume of parathyroid adenoma. Carboxyl-terminal parathyroid hormone (C-PTH), amino-terminal parathyroid hormone (N-PTH), nephrogenous cyclic AMP (N-CAMP), and other markers of calcium metabolism were measured with standard techniques. Tumors were divided into small ( < 1.0 cm<sup>3</sup>) or large (≧1.0 cm<sup>3</sup>) sizes. N-PTH and C-PTH measurements were increased in 10% and 30% of patients with small tumors and in 71 and 78% of patients with large tumors. Serum calcium, N-CAMP, C-PTH and N-PTH tended to be greater with large tumors, but only C-PTH was significant. We concluded that the size of parathyroid adenoma influenced biochemical measurements of its activity and that the measurements of PTH in patients with small tumors are not as sensitive as those in patients with large tumors.

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Journal ID (publisher-id): HRE

Journal ID (nlm-ta): Horm Res Paediatr

Journal ID (doi): 10.1159/issn.1663-2818

Title: Hormone Research in Paediatrics

Publisher: S. Karger AG

ISSN (Print): 1663-2818

ISSN (Electronic): 1663-2826

Publication date Subscription-year: 1989

Publication date (Print): 1989

Publication date (Electronic): 02 December 2008

Volume: 32

Issue: 4

Pages: 142-144

Affiliations

Departments of Endocrinology Metabolism, Surgery and Immunopathology, Cleveland Clinic, Cleveland, Ohio, USA

Article

Publisher ID: 181276 Other ID: Horm Res 1989;32:142–144

DOI: 10.1159/000181276

PubMed ID: 2560456

SO-VID: 2992271f-84f1-42d5-96a9-1905dfb5b84c

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Relationship of Parathyroid Adenoma Volume and Biochemical Function

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Karger: Endocrinology

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