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      Glomerular Refractoriness to Contractile Stimuli in Rabbits Recovering from Ischemic Acute Renal Failure

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          Abstract

          The present work was performed on uninephrectomized rabbits recovering from ischemic acute renal failure (ARF) in an attempt to elucidate whether or not intraglomerular events are a determinant factor in the development of resistance to ARF. 14 days after a 2-hour clamping of the renal artery (the recovery phase), the animals did not show resistance to an additional ischemia. On the other hand, glomeruli derived from normal kidneys displayed a contractile response to angiotensin II, arginine vasopressin or norepinephrine in Eagle’s minimum essential medium, whereas glomeruli from rabbits recovering from ischemic ARF were refractory to the vasoconstrictor agents. The findings suggest that glomerular refractoriness to contractile stimuli does not provide resistance to an additional renal ischemia in the ischemic model of ARF

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1988
          1988
          09 December 2008
          : 48
          : 4
          : 306-309
          Affiliations
          First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
          Article
          184948 Nephron 1988;48:306–309
          10.1159/000184948
          3362277
          © 1988 S. Karger AG, Basel

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          Page count
          Pages: 4
          Categories
          Original Paper

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