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      Alpha/Beta Interferon Is a Neuronal Growth Factor

      research-article
      a, b , a
      Neuroimmunomodulation
      S. Karger AG
      Interferon, Growth factor, Tissue culture

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          Abstract

          We investigated the effect of alpha/beta interferon on neuronal survivability. E16 murine telencephalic vesicles were dissected aseptically and grown on collagen-coated coverslips. After 2 weeks of culturing, the media was supplemented with mouse alpha/beta interferon (1,500 U/ml). After an additional 2 weeks of culturing, all of the control cultures demonstrated significant neuronal death. In the 16 interferon-treated cultures, neuronal death took place only in 1 culture, baseline survivability occurred in 2 and proliferation in 13 cultures (p < 0.005). Thus, alpha/beta interferon sustains neuronal growth.

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          Author and article information

          Journal
          NIM
          Neuroimmunomodulation
          10.1159/issn.1021-7401
          Neuroimmunomodulation
          S. Karger AG
          1021-7401
          1423-0216
          1995
          1995
          22 May 1995
          : 2
          : 1
          : 31-35
          Affiliations
          a Division of Neurology, Mercy Hospital andMedical Center, and b Department of Neurology, University ofIllinois, Chicago, Ill., USA
          Article
          96838 Neuroimmunomodulation 1995;2:31–35
          10.1159/000096838
          7614258
          29ccec33-f109-47fc-805b-f0f874dea4f4
          © 1995 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          Page count
          Pages: 5
          Categories
          Original Paper

          Endocrinology & Diabetes,Neurology,Nutrition & Dietetics,Sexual medicine,Internal medicine,Pharmacology & Pharmaceutical medicine
          Growth factor,Tissue culture,Interferon

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