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      Joint L 1/2-Norm Constraint and Graph-Laplacian PCA Method for Feature Extraction

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          Abstract

          Principal Component Analysis (PCA) as a tool for dimensionality reduction is widely used in many areas. In the area of bioinformatics, each involved variable corresponds to a specific gene. In order to improve the robustness of PCA-based method, this paper proposes a novel graph-Laplacian PCA algorithm by adopting L 1/2 constraint ( L 1/2 gLPCA) on error function for feature (gene) extraction. The error function based on L 1/2-norm helps to reduce the influence of outliers and noise. Augmented Lagrange Multipliers (ALM) method is applied to solve the subproblem. This method gets better results in feature extraction than other state-of-the-art PCA-based methods. Extensive experimental results on simulation data and gene expression data sets demonstrate that our method can get higher identification accuracies than others.

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          Most cited references44

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          De-noising by soft-thresholding

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            ToppGene Suite for gene list enrichment analysis and candidate gene prioritization

            ToppGene Suite (http://toppgene.cchmc.org; this web site is free and open to all users and does not require a login to access) is a one-stop portal for (i) gene list functional enrichment, (ii) candidate gene prioritization using either functional annotations or network analysis and (iii) identification and prioritization of novel disease candidate genes in the interactome. Functional annotation-based disease candidate gene prioritization uses a fuzzy-based similarity measure to compute the similarity between any two genes based on semantic annotations. The similarity scores from individual features are combined into an overall score using statistical meta-analysis. A P-value of each annotation of a test gene is derived by random sampling of the whole genome. The protein–protein interaction network (PPIN)-based disease candidate gene prioritization uses social and Web networks analysis algorithms (extended versions of the PageRank and HITS algorithms, and the K-Step Markov method). We demonstrate the utility of ToppGene Suite using 20 recently reported GWAS-based gene–disease associations (including novel disease genes) representing five diseases. ToppGene ranked 19 of 20 (95%) candidate genes within the top 20%, while ToppNet ranked 12 of 16 (75%) candidate genes among the top 20%.
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              Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

              On the subject of acute myeloid leukemia (AML), there is little consensus about the target cell within the hematopoietic stem cell hierarchy that is susceptible to leukemic transformation, or about the mechanism that underlies the phenotypic, genotypic and clinical heterogeneity. Here we demonstrate that the cell capable of initiating human AML in non-obese diabetic mice with severe combined immunodeficiency disease (NOD/SCID mice) - termed the SCID leukemia-initiating cell, or SL-IC - possesses the differentiative and proliferative capacities and the potential for self-renewal expected of a leukemic stem cell. The SL-ICs from all subtypes of AML analyzed, regardless of the heterogeneity in maturation characteristics of the leukemic blasts, were exclusively CD34++ CD38-, similar to the cell-surface phenotype of normal SCID-repopulating cells, suggesting that normal primitive cells, rather than committed progenitor cells, are the target for leukemic transformation. The SL-ICs were able to differentiate in vivo into leukemic blasts, indicating that the leukemic clone is organized as a hierarchy.
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                Author and article information

                Journal
                Biomed Res Int
                Biomed Res Int
                BMRI
                BioMed Research International
                Hindawi
                2314-6133
                2314-6141
                2017
                2 April 2017
                : 2017
                : 5073427
                Affiliations
                1School of Information Science and Engineering, Qufu Normal University, Rizhao 276826, China
                2Library of Qufu Normal University, Qufu Normal University, Rizhao 276826, China
                Author notes

                Academic Editor: Jialiang Yang

                Author information
                https://orcid.org/http://orcid.org/0000-0002-3044-9779
                https://orcid.org/http://orcid.org/0000-0003-0483-5622
                https://orcid.org/http://orcid.org/0000-0001-6104-2149
                Article
                10.1155/2017/5073427
                5392409
                29cfecff-0729-45c8-ad9d-90e71454dcd1
                Copyright © 2017 Chun-Mei Feng et al.

                This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 30 December 2016
                : 12 February 2017
                : 1 March 2017
                Funding
                Funded by: National Natural Science Foundation of China
                Award ID: 61572284
                Award ID: 61502272
                Categories
                Research Article

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