13
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Psychosocial therapy for Parkinson's-related dementia: study protocol for the INVEST randomised controlled trial

      protocol

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Introduction

          Parkinson's disease (PD) with mild cognitive impairment (MCI-PD) or dementia (PDD) and dementia with Lewy bodies (DLB) are characterised by motor and ‘non-motor’ symptoms which impact on quality of life. Treatment options are generally limited to pharmacological approaches. We developed a psychosocial intervention to improve cognition, quality of life and companion burden for people with MCI-PD, PDD or DLB. Here, we describe the protocol for a single-blind randomised controlled trial to assess feasibility, acceptability and tolerability of the intervention and to evaluate treatment implementation. The interaction among the intervention and selected outcome measures and the efficacy of this intervention in improving cognition for people with MCI-PD, PDD or DLB will also be explored.

          Methods and analysis

          Dyads will be randomised into two treatment arms to receive either ‘treatment as usual’ (TAU) or cognitive stimulation therapy specifically adapted for Parkinson's-related dementias (CST-PD), involving 30 min sessions delivered at home by the study companion three times per week over 10 weeks. A mixed-methods approach will be used to collect data on the operational aspects of the trial and treatment implementation. This will involve diary keeping, telephone follow-ups, dyad checklists and researcher ratings. Analysis will include descriptive statistics summarising recruitment, acceptability and tolerance of the intervention, and treatment implementation. To pilot an outcome measure of efficacy, we will undertake an inferential analysis to test our hypothesis that compared with TAU, CST-PD improves cognition. Qualitative approaches using thematic analysis will also be applied. Our findings will inform a larger definitive trial.

          Ethics and dissemination

          Ethical opinion was granted (REC reference: 15/YH/0531). Findings will be published in peer-reviewed journals and at conferences. We will prepare reports for dissemination by organisations involved with PD and dementia.

          Trial registration number

          ISRCTN (ISRCTN11455062).

          Related collections

          Most cited references23

          • Record: found
          • Abstract: found
          • Article: not found

          EuroQol: the current state of play.

          R. Brooks (1996)
          The EuroQol Group first met in 1987 to test the feasibility of jointly developing a standardised non-disease-specific instrument for describing and valuing health-related quality of life. From the outset the Group has been multi-country, multi-centre, and multi-disciplinary. The EuroQol instrument is intended to complement other forms of quality of life measures, and it has been purposefully developed to generate a cardinal index of health, thus giving it considerable potential for use in economic evaluation. Considerable effort has been invested by the Group in the development and valuation aspects of health status measurement. Earlier work was reported upon in 1990; this paper is a second 'corporate' effort detailing subsequent developments. The concepts underlying the EuroQol framework are explored with particular reference to the generic nature of the instrument. The valuation task is reviewed and some evidence on the methodological requirements for measurement is presented. A number of special issues of considerable interest and concern to the Group are discussed: the modelling of data, the duration of health states and the problems surrounding the state 'dead'. An outline of some of the applications of the EuroQol instrument is presented and a brief commentary on the Group's ongoing programme of work concludes the paper.
            Bookmark
            • Record: found
            • Abstract: found
            • Article: found

            Validation of the Addenbrooke's Cognitive Examination III in Frontotemporal Dementia and Alzheimer's Disease

            Background/Aims: The aims of this study were to validate the newly developed version of the Addenbrooke's Cognitive Examination (ACE-III) against standardised neuropsychological tests and its predecessor (ACE-R) in early dementia. Methods: A total of 61 patients with dementia (frontotemporal dementia, FTD, n = 33, and Alzheimer's disease, AD, n = 28) and 25 controls were included in the study. Results: ACE-III cognitive domains correlated significantly with standardised neuropsychological tests used in the assessment of attention, language, verbal memory and visuospatial function. The ACE-III also compared very favourably with its predecessor, the ACE-R, with similar levels of sensitivity and specificity. Conclusion: The results of this study provide objective validation of the ACE-III as a screening tool for cognitive deficits in FTD and AD.
              Bookmark
              • Record: found
              • Abstract: not found
              • Book Chapter: not found

              Assessment of Individual Differences in Empathy

              Mark Davis (2018)
                Bookmark

                Author and article information

                Journal
                BMJ Open
                BMJ Open
                bmjopen
                bmjopen
                BMJ Open
                BMJ Publishing Group (BMA House, Tavistock Square, London, WC1H 9JR )
                2044-6055
                2017
                19 June 2017
                : 7
                : 6
                : e016801
                Affiliations
                [1 ] departmentDivision of Neuroscience and Experimental Psychology , University of Manchester , Manchester, UK
                [2 ] Manchester Academic Health Science Centre , Manchester, UK
                [3 ] Greater Manchester Mental Health NHS Foundation Trust , Manchester, UK
                [4 ] departmentDivision of Psychiatry , University College London , London, UK
                [5 ] departmentFaculty of Health Studies , University of Bradford , Bradford, UK
                [6 ] departmentGreater Manchester Neurosciences Centre , Salford Royal NHS Foundation Trust , Salford, UK
                Author notes
                [Correspondence to ] Dr Iracema Leroi; iracema.leroi@ 123456manchester.ac.uk
                Article
                bmjopen-2017-016801
                10.1136/bmjopen-2017-016801
                5726123
                28630086
                29ea758d-907c-4733-bb77-78304cd19b84
                © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

                This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/

                History
                : 10 March 2017
                : 16 March 2017
                Funding
                Funded by: FundRef http://dx.doi.org/10.13039/501100001921, Public Health Research Programme;
                Categories
                Research Methods
                Protocol
                1506
                1730
                Custom metadata
                unlocked

                Medicine
                feasibility and exploratory study,pilot trial,complex intervention,psychosocial therapy,quality of life,parkinson's disease dementia (pdd),mild cognitive impairment in pd (mci-pd),dementia with lewy bodies (dlb),process analysis.

                Comments

                Comment on this article