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      Chronic transcranial focal stimulation from tripolar concentric ring electrodes does not disrupt memory formation in rats.

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          Abstract

          Non-invasive electrical brain stimulation has shown potential utility as a treatment for seizures in epilepsy patients. Transcranial focal stimulation (TFS) via tripolar concentric ring electrodes (TCREs) has been effective in reducing seizure severity in acute rodent models, but it has yet to be determined whether or not it will serve as a viable long-term treatment strategy. Prior experiments indicate that a single dose of TFS via TCRE does not impact short- or long-term memory formation. The present study investigated if five daily doses of TFS via a TCRE on the scalp affected the memory. The spontaneous object recognition (SOR) test was used to evaluate the memory. Sham and TFS-treated groups were evaluated and both showed comparable levels of preference for novel objects, indicating successful memory formation. More work on repeated dosage strategies is important for establishing the safety and efficacy of TFS as a putative treatment.

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          Author and article information

          Journal
          Conf Proc IEEE Eng Med Biol Soc
          Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
          Institute of Electrical and Electronics Engineers (IEEE)
          1557-170X
          1557-170X
          2014
          : 2014
          Article
          10.1109/EMBC.2014.6945030
          25571398
          29fa0516-1248-4391-be4e-646fd579f851
          History

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