Association of Delivery Mode With Pelvic Floor Disorders After Childbirth

Abstract

<div class="section"> <a class="named-anchor" id="ab-joi180141-1"> <!-- named anchor --> </a> <h5 class="section-title" id="d9651273e261">Question</h5> <p id="d9651273e263">Is childbirth delivery mode associated with risk of pelvic floor disorders over time?</p> </div><div class="section"> <a class="named-anchor" id="ab-joi180141-2"> <!-- named anchor --> </a> <h5 class="section-title" id="d9651273e266">Findings</h5> <p id="d9651273e268">In this cohort study of 1528 women, compared with spontaneous vaginal delivery, cesarean delivery was associated with a significantly lower risk of stress urinary incontinence (adjusted hazard ratio [aHR], 0.46), overactive bladder (aHR, 0.51), and pelvic organ prolapse (aHR, 0.28); operative vaginal delivery was associated with a significantly higher risk of anal incontinence (aHR, 1.75) and pelvic organ prolapse (aHR, 1.88). </p> </div><div class="section"> <a class="named-anchor" id="ab-joi180141-3"> <!-- named anchor --> </a> <h5 class="section-title" id="d9651273e271">Meaning</h5> <p id="d9651273e273">After childbirth, the risk of pelvic floor disorders varied by delivery mode.</p> </div><div class="section"> <a class="named-anchor" id="ab-joi180141-4"> <!-- named anchor --> </a> <h5 class="section-title" id="d9651273e277">Importance</h5> <p id="d9651273e279">Pelvic floor disorders (eg, urinary incontinence), which affect approximately 25% of women in the United States, are associated with childbirth. However, little is known about the course and progression of pelvic floor disorders over time. </p> </div><div class="section"> <a class="named-anchor" id="ab-joi180141-5"> <!-- named anchor --> </a> <h5 class="section-title" id="d9651273e282">Objective</h5> <p id="d9651273e284">To describe the incidence of pelvic floor disorders after childbirth and identify maternal and obstetrical characteristics associated with patterns of incidence 1 to 2 decades after delivery. </p> </div><div class="section"> <a class="named-anchor" id="ab-joi180141-6"> <!-- named anchor --> </a> <h5 class="section-title" id="d9651273e287">Design, Setting, and Participants</h5> <p id="d9651273e289">Women were recruited from a community hospital for this cohort study 5 to 10 years after their first delivery and followed up annually for up to 9 years. Recruitment was based on mode of delivery; delivery groups were matched for age and years since first delivery. Of 4072 eligible women, 1528 enrolled between October 2008 and December 2013. Annual follow-up continued through April 2017. </p> </div><div class="section"> <a class="named-anchor" id="ab-joi180141-7"> <!-- named anchor --> </a> <h5 class="section-title" id="d9651273e292">Exposures</h5> <p id="d9651273e294">Participants were categorized into the following mode of delivery groups: cesarean birth (cesarean deliveries only), spontaneous vaginal birth (≥1 spontaneous vaginal delivery and no operative vaginal deliveries), or operative vaginal birth (≥1 operative vaginal delivery). </p> </div><div class="section"> <a class="named-anchor" id="ab-joi180141-8"> <!-- named anchor --> </a> <h5 class="section-title" id="d9651273e297">Main Outcomes and Measures</h5> <p id="d9651273e299">Stress urinary incontinence (SUI), overactive bladder (OAB), and anal incontinence (AI), defined using validated threshold scores from the Epidemiology of Prolapse and Incontinence Questionnaire, and pelvic organ prolapse (POP), measured using the Pelvic Organ Prolapse Quantification Examination. Cumulative incidences, by delivery group, were estimated using parametric methods. Hazard ratios, by exposure, were estimated using semiparametric models. </p> </div><div class="section"> <a class="named-anchor" id="ab-joi180141-9"> <!-- named anchor --> </a> <h5 class="section-title" id="d9651273e302">Results</h5> <p id="d9651273e304">Among 1528 women (778 in the cesarean birth group, 565 in the spontaneous vaginal birth group, and 185 in the operative vaginal birth group), the median age at first delivery was 30.6 years, 1092 women (72%) were multiparous at enrollment (2887 total deliveries), and the median age at enrollment was 38.3 years. During a median follow-up of 5.1 years (7804 person-visits), there were 138 cases of SUI, 117 cases of OAB, 168 cases of AI, and 153 cases of POP. For spontaneous vaginal delivery (reference), the 15-year cumulative incidences of pelvic floor disorders after first delivery were as follows: SUI, 34.3% (95% CI, 29.9%-38.6%); OAB, 21.8% (95% CI, 17.8%-25.7%); AI, 30.6% (95% CI, 26.4%-34.9%), and POP, 30.0% (95% CI, 25.1%-34.9%). Compared with spontaneous vaginal delivery, cesarean delivery was associated with significantly lower hazard of SUI (adjusted hazard ratio [aHR], 0.46 [95% CI, 0.32-0.67]), OAB (aHR, 0.51 [95% CI, 0.34-0.76]), and POP (aHR, 0.28 [95% CI, 0.19-0.42]), while operative vaginal delivery was associated with significantly higher hazard of AI (aHR, 1.75 [95% CI, 1.14-2.68]) and POP (aHR, 1.88 [95% CI, 1.28-2.78]). Stratifying by delivery mode, the hazard ratios for POP, relative to a genital hiatus size less than or equal to 2.5 cm, were 3.0 (95% CI, 1.7-5.3) for a genital hiatus size of 3 cm and 9.0 (95% CI, 5.5-14.8) for a genital hiatus size greater than or equal to 3.5 cm. </p> </div><div class="section"> <a class="named-anchor" id="ab-joi180141-10"> <!-- named anchor --> </a> <h5 class="section-title" id="d9651273e307">Conclusions and Relevance</h5> <p id="d9651273e309">Compared with spontaneous vaginal delivery, cesarean delivery was associated with significantly lower hazard for stress urinary incontinence, overactive bladder, and pelvic organ prolapse, while operative vaginal delivery was associated with significantly higher hazard of anal incontinence and pelvic organ prolapse. A larger genital hiatus was associated with increased risk of pelvic organ prolapse independent of delivery mode. </p> </div><p class="first" id="d9651273e312">This cohort study describes the incidence of urinary incontinence, organ prolapse, and other pelvic floor disorders among women who gave birth via cesarean, spontaneous vaginal, or operative vaginal delivery. </p>