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      Low Catalase Activity in Rats with Ureteral Ligation: Relation to Lipid Peroxidation

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          Abstract

          Progression of some renal diseases is characterized by generation of reactive oxygen metabolites that are also involved in the pathophysiology of obstructive nephropathy. Catalase activity and lipid peroxidation were investigated in rats with unilaterally (UUL) and bilaterally ligated ureters (BUL). Forty-eight hours after ligation, the animals were sacrificed, and enzyme activity as well as the malondialdehyde (MDA) concentration were measured in the plasma, kidneys and livers. The activity of catalase was significantly reduced in the plasma of the BUL rats and in the kidneys of both investigated groups. In the liver, catalase activity was decreased only in the BUL group. The MDA concentration in the plasma and kidneys of the BUL rats was significantly increased while in the liver it remained unchanged. These results suggest that lipid peroxidation in the induced uremic state could be responsible for catalase inactivation.

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          Author and article information

          Journal
          EXN
          Nephron Exp Nephrol
          10.1159/issn.1660-2129
          Cardiorenal Medicine
          S. Karger AG
          1660-2129
          1998
          February 1998
          04 February 1998
          : 6
          : 1
          : 74-77
          Affiliations
          a Institute of Biochemistry, Faculty of Medicine, and b Institute of Nephrology and Hemodialysis, Clinical Center, Niš, Yugoslavia
          Article
          20507 Exp Nephrol 1998;6:74–77
          10.1159/000020507
          2a095e45-28f5-46d7-acee-d8cc1c347117
          © 1998 S. Karger AG, Basel

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          History
          Page count
          Tables: 4, References: 12, Pages: 4
          Categories
          Brief Communication

          Cardiovascular Medicine,Nephrology
          Catalase activity,Ureteral ligation,Lipid peroxidation
          Cardiovascular Medicine, Nephrology
          Catalase activity, Ureteral ligation, Lipid peroxidation

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