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Targeting tumors with non-viral gene delivery systems
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Abstract
Targeting therapeutic genes to tumors is an attractive concept in curing malignant
diseases. Systemic gene delivery systems are needed for therapeutic applications in
which the target cells are not directly accessible, and which can only be reached
via the systemic route. Recent developments in the field of non-viral gene delivery
have shown that, based on (poly)cationic carrier molecules, DNA can be efficiently
targeted to tumors via the bloodstream. Tailor-made synthetic vectors can be used
to achieve predominant gene expression in tumor tissue. Therapeutic concepts based,
for example, on suicide genes or cytokines, showed encouraging results in preclinical
and also in first clinical evaluations.