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      High prevalence of obesity in severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) requiring invasive mechanical ventilation

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          Abstract

          Objective

          The Covid‐19 pandemic is rapidly spreading worldwide, notably in Europe and North America, where obesity is highly prevalent. The relation between obesity and severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) has not been fully documented.

          Methods

          In this retrospective cohort study we analyzed the relationship between clinical characteristics, including body mass index (BMI), and the requirement for invasive mechanical ventilation (IMV) in 124 consecutive patients admitted in intensive care for SARS‐CoV‐2, in a single French center.

          Results

          Obesity (BMI >30 kg/m2) and severe obesity (BMI >35 kg/m2) were present in 47.6% and 28.2% of cases, respectively. Overall, 85 patients (68.6%) required IMV. The proportion of patients who required IMV increased with BMI categories (p<0.01, Chi square test for trend), and it was greatest in patients with BMI >35 kg/m2 (85.7%). In multivariate logistic regression, the need for IMV was significantly associated with male sex (p<0.05) and BMI (p<0.05), independent of age, diabetes, and hypertension. The odds ratio for IMV in patients with BMI >35 kg/m2 vs patients with BMI <25 kg/m2 was 7.36 (1.63‐33.14; p=0.02)

          Conclusion

          The present study showed a high frequency of obesity among patients admitted in intensive care for SARS‐CoV‐2. Disease severity increased with BMI. Obesity is a risk factor for SARS‐CoV‐2 severity requiring increased attention to preventive measures in susceptible individuals.

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          Author and article information

          Contributors
          francois.pattou@univ-lille.fr
          mercedes.jourdain@univ-lille.fr
          Journal
          Obesity (Silver Spring)
          Obesity (Silver Spring)
          10.1002/(ISSN)1930-739X
          OBY
          Obesity (Silver Spring, Md.)
          John Wiley and Sons Inc. (Hoboken )
          1930-7381
          1930-739X
          09 April 2020
          : 10.1002/oby.22831
          Affiliations
          [ 1 ] CHU Lille Department of Intensive Care 59000 Lille France
          [ 2 ] Inserm Univ Lille, CHU Lille Lille Pasteur Institute EGID, U1190 59000 Lille France
          [ 3 ] Univ Lille CHU Lille ULR 2694 METRICS F59000 Lille France
          [ 4 ] CHU Lille Integrated Center for Obesity 59000 Lille France
          Author notes
          [†]

          Co‐first authors

          Author information
          https://orcid.org/0000-0001-5754-2028
          Article
          OBY22831
          10.1002/oby.22831
          7262326
          32271993
          2a1c7444-6392-40d2-8aad-7c96094a12ba
          This article is protected by copyright. All rights reserved.

          This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.

          History
          Page count
          Figures: 0, Tables: 0, Pages: 15, Words: 409
          Categories
          Brief Cutting Edge Reports
          Brief Cutting Edge Reports
          Custom metadata
          2.0
          accepted-manuscript
          Converter:WILEY_ML3GV2_TO_JATSPMC version:5.8.3 mode:remove_FC converted:01.06.2020

          Medicine
          obesity,body mass index,sras‐cov‐2,covid‐19,mechanical ventilation,intensive care
          Medicine
          obesity, body mass index, sras‐cov‐2, covid‐19, mechanical ventilation, intensive care

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