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      Effect of Intradialytic Exercise on Physical Performance and Cardiovascular Risk Factors in Patients Receiving Maintenance Hemodialysis: A Pilot and Feasibility Study

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          Introduction: Although intradialytic exercise is considered a form of “nonpharmacological medicine” for patients receiving maintenance hemodialysis (MHD), this practice has not been widely implemented in most dialysis centers because of clinical limitations. We, therefore, aimed to design an intradialytic exercise training program to improve the implementation of this practice and determine its impact on physical performance and cardiovascular risk factors in patients receiving MHD. Methods: A total of 132 MHD patients at 4 outpatient dialysis units were enrolled and assigned randomly into exercise ( n = 67) and control groups ( n = 65). During a 2-year period, patients in the exercise group participated in 20-min exercise training sessions within dialysis sessions on 3 days per week. All patients underwent assessments of physical function (6-min walk test) and cardiovascular risk factors (blood pressure [BP], total cholesterol [TC], low-density lipoprotein [LDL], high-sensitivity C-reactive protein [hsCRP], albumin [Alb], hemoglobin [Hb], and erythropoietin [EPO] dose) at the baseline and annually thereafter. Results: Of the participants, 50.8% had completed the study after 2 years. No statistically significant intragroup or intergroup differences were observed in the measures of 6MD, BP, TC, hsCRP, Alb, Hb, and EPO dose. Conclusion: The results suggest that although this low-intensity, nonprogressive intradialytic exercise program may be practical, it was not sufficient to improve physiological function and reduce cardiovascular disease risk factors in patients receiving MHD.

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          Author and article information

          Blood Purif
          Blood Purification
          S. Karger AG
          July 2020
          19 December 2019
          : 49
          : 4
          : 409-418
          aDepartment of Nephrology, China Rehabilitation Research Center, Beijing Boai Hospital, Capital Medical University Rehabilitation Medical College, Beijing, China
          bDepartment of Nephrology, Peking University People’s Hospital, Beijing, China
          cDepartment of Nephrology, ChuiYangLiu Hospital Affiliated with Tsinghua University, Beijing, China
          dDepartment of Nephrology, Beijing Zhanlanlu Hospital, Beijing, China
          Author notes
          *Ying-Chun Ma, Department of Nephrology, China Rehabilitation Research Center, Beijing Boai Hospital, Capital Medical University Rehabilitation Medical College, No. 10, Jiao Men North Street, FengTai, Beijing 100068 (China), E-Mail mych323@163.com
          504955 Blood Purif 2020;49:409–418
          © 2019 S. Karger AG, Basel

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          Page count
          Figures: 8, Tables: 2, Pages: 10
          Research Article


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