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      Significant decreases of ulinastatin-like immunoreactive substance in the cerebrospinal fluid of patients with dementia.

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          Abstract

          Studies to elucidate changes in the contents of ulinastatin-like immunoreactive substance (UTIRS) and alpha 1-microglobulin-like immunoreactive substance (alpha 1 MIRS) in cerebrospinal fluid (CSF) of patients with dementia were performed. Levels of UTIRS in the dementia group were significantly (p < 0.01) lower than those in dementia-free subjects. In addition, lower levels of UTIRS were registered in subjects afflicted with a higher severity of dementia. However, the levels of alpha 1 MIRS were not affected in the dementia group compared with dementia-free subjects. Neither UTIRS nor alpha 1 MIRS contents were related to the existence and stages of Parkinson's disease. These results suggest that UTIRS levels in the CSF are associated with the severity of dementia.

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          Author and article information

          Journal
          Neuropsychobiology
          Neuropsychobiology
          S. Karger AG
          0302-282X
          0302-282X
          1997
          : 35
          : 4
          Affiliations
          [1 ] Department of Pharmacology, Shimane Medical University, Japan.
          Article
          10.1159/000119402
          9246219
          2a29b943-0924-4e9b-87ff-60e219336282
          History

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