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      Anticancer carbazole alkaloids and coumarins from Clausena plants: A review

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          Abstract

          Pharmaceutical research has focused on the discovery and development of anticancer drugs. Clinical application of chemotherapy drugs is limited due to their severe side effects. In this regard, new naturally occurring anticancer drugs have gained increasing attention because of their potential effectiveness and safety. Fruits and vegetables are promising sources of anticancer remedy. Clausena (family Rutaceae) is a genus of flowering plants and includes several kinds of edible fruits and vegetables. Phytochemical and pharmacological studies show that carbazole alkaloids and coumarins from Clausena plants exhibit anticancer activity. This review summarizes research progresses made in the anticancer properties of plants belonging to Clausena; in particular, compounds with direct cytotoxicity, cell cycle arrest, apoptosis induction, and immune potentiation effects are discussed. This review reveals the potential use of plants from Clausena in preventing and treating cancer and provides a basis for development of relevant therapeutic agents.

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          Author and article information

          Journal
          CJNM
          Chinese Journal of Natural Medicines
          Elsevier
          1875-5364
          20 December 2017
          : 15
          : 12
          : 881-888
          Affiliations
          1State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China
          Author notes
          *Corresponding author: LIN Li-Gen, Tel: +853-88228041, Fax: +853-28841358; E-mail: ligenl@ 123456umac.mo .

          These authors have no conflict of interest to declare.

          Article
          S1875-5364(18)30003-7
          10.1016/S1875-5364(18)30003-7
          Copyright © 2017 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
          Funding
          Funded by: Macao Science and Technology Development Fund
          Award ID: 120/2013/A3
          Funded by: Research Fund of University of Macau
          Award ID: MYRG2015-00153-ICMSQRCM and MYRG2017-00109-ICMS
          This work is supported by the Macao Science and Technology Development Fund (No. 120/2013/A3) and the Research Fund of University of Macau (Nos. MYRG2015- 00153-ICMSQRCM and MYRG2017-00109-ICMS).
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          Review

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