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      Serum microRNA expression profile: miR-1246 as a novel diagnostic and prognostic biomarker for oesophageal squamous cell carcinoma

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          Abstract

          Background:

          Recent studies have demonstrated that microRNAs (miRNAs) are stably detectable in blood and can serve as useful biomarkers for cancer.

          Methods:

          We performed an miRNA array using serum samples obtained from oesophageal squamous cell carcinoma (ESCC) patients or healthy controls. MiR-1246 was the most markedly elevated in ESCC patients. Therefore, miR-1246 was selected as a candidate for further analysis. The serum miR-1246 level in 46 healthy controls and 101 ESCC patients was evaluated and compared among various clinicopathological characteristics. MiR-1246 expressions in tissue, exosomal, and cellular samples were also examined.

          Results:

          Serum miR-1246 alone yielded an receiver-operating characteristic curve area of 0.754, with 71.3% sensitivity and 73.9% specificity for distinguishing ESCC patients from healthy controls. Serum miR-1246 was significantly correlated with the TNM stage and showed to be the strongest independent risk factor for poor survival (HR, 4.032; P=0.017). Unlike the tendency shown in previous reports, miR-1246 was not upregulated in ESCC tissue samples. Furthermore, exosomal miR-1246 did not reflect the abundance in the cell of origin.

          Conclusion:

          These data support our contention that serum miR-1246 has strong potential as a novel diagnostic and prognostic biomarker in ESCC, and its releasing mechanism is selective and independent of tissue miRNA abundance.

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          Author and article information

          Journal
          Br J Cancer
          Br. J. Cancer
          British Journal of Cancer
          Nature Publishing Group
          0007-0920
          1532-1827
          19 February 2013
          29 January 2013
          : 108
          : 3
          : 644-652
          Affiliations
          [1 ]Department of Frontier Surgery, Chiba University Graduate School of Medicine , Inohana 1-8-1, Chuo-ku, Chiba 260 8670, Japan
          Author notes
          Article
          bjc20138
          10.1038/bjc.2013.8
          3593570
          23361059
          Copyright © 2013 Cancer Research UK

          From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/

          Categories
          Molecular Diagnostics

          Oncology & Radiotherapy

          serum microrna, mir-1246, oesophageal squamous cell carcinoma, biomarker

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