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      Intercontinental spread of pyrimethamine-resistant malaria.

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          Abstract

          Here we present molecular evidence demonstrating that malaria parasites bearing high-level pyrimethamine resistance originally arrived in Africa from southeast Asia. The resistance alleles carried by these migrants are now spreading across Africa at an alarming rate, signaling the end of affordable malaria treatment and presenting sub-Saharan Africa with a public health crisis.

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          Author and article information

          Journal
          Science
          Science (New York, N.Y.)
          American Association for the Advancement of Science (AAAS)
          1095-9203
          0036-8075
          Aug 20 2004
          : 305
          : 5687
          Affiliations
          [1 ] London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK. cally.roper@lshtm.ac.uk
          Article
          305/5687/1124
          10.1126/science.1098876
          15326348
          2a4c38bf-d7f1-4068-91f8-955f57f7502a
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