Blog
About

54
views
0
recommends
+1 Recommend
0 collections
    5
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Prostaglandins and inflammation.

      Arteriosclerosis, Thrombosis, and Vascular Biology

      Animals, metabolism, Thromboxanes, drug effects, Signal Transduction, Receptors, Prostaglandin, Prostaglandins, Prostaglandin-Endoperoxide Synthases, Inflammation Mediators, immunology, drug therapy, Inflammation, Humans, therapeutic use, Cyclooxygenase Inhibitors

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Prostaglandins are lipid autacoids derived from arachidonic acid. They both sustain homeostatic functions and mediate pathogenic mechanisms, including the inflammatory response. They are generated from arachidonate by the action of cyclooxygenase isoenzymes, and their biosynthesis is blocked by nonsteroidal antiinflammatory drugs, including those selective for inhibition of cyclooxygenase-2. Despite the clinical efficacy of nonsteroidal antiinflammatory drugs, prostaglandins may function in both the promotion and resolution of inflammation. This review summarizes insights into the mechanisms of prostaglandin generation and the roles of individual mediators and their receptors in modulating the inflammatory response. Prostaglandin biology has potential clinical relevance for atherosclerosis, the response to vascular injury and aortic aneurysm.

          Related collections

          Author and article information

          Journal
          21508345
          3081099
          10.1161/ATVBAHA.110.207449

          Comments

          Comment on this article