Advance care planning in patients with advanced cancer: A 6-country, cluster-randomised clinical trial

Abstract

Background

Advance care planning (ACP) supports individuals to define, discuss, and record goals and preferences for future medical treatment and care. Despite being internationally recommended, randomised clinical trials of ACP in patients with advanced cancer are scarce.

Methods and findings

To test the implementation of ACP in patients with advanced cancer, we conducted a cluster-randomised trial in 23 hospitals across Belgium, Denmark, Italy, Netherlands, Slovenia, and United Kingdom in 2015–2018. Patients with advanced lung (stage III/IV) or colorectal (stage IV) cancer, WHO performance status 0–3, and at least 3 months life expectancy were eligible. The ACTION Respecting Choices ACP intervention as offered to patients in the intervention arm included scripted ACP conversations between patients, family members, and certified facilitators; standardised leaflets; and standardised advance directives. Control patients received care as usual. Main outcome measures were quality of life (operationalised as European Organisation for Research and Treatment of Cancer [EORTC] emotional functioning) and symptoms. Secondary outcomes were coping, patient satisfaction, shared decision-making, patient involvement in decision-making, inclusion of advance directives (ADs) in hospital files, and use of hospital care. In all, 1,117 patients were included (442 intervention; 675 control), and 809 (72%) completed the 12-week questionnaire. Patients’ age ranged from 18 to 91 years, with a mean of 66; 39% were female. The mean number of ACP conversations per patient was 1.3. Fidelity was 86%. Sixteen percent of patients found ACP conversations distressing. Mean change in patients’ quality of life did not differ between intervention and control groups (T-score −1.8 versus −0.8, p = 0.59), nor did changes in symptoms, coping, patient satisfaction, and shared decision-making. Specialist palliative care (37% versus 27%, p = 0.002) and AD inclusion in hospital files (10% versus 3%, p < 0.001) were more likely in the intervention group. A key limitation of the study is that recruitment rates were lower in intervention than in control hospitals.

Conclusions

Our results show that quality of life effects were not different between patients who had ACP conversations and those who received usual care. The increased use of specialist palliative care and AD inclusion in hospital files of intervention patients is meaningful and requires further study. Our findings suggest that alternative approaches to support patient-centred end-of-life care in this population are needed.

Trial registration

ISRCTN registry ISRCTN63110516.

Abstract

Giulia Carreras and colleagues report the implementation of advanced care planning in patients with advanced cancer.

Author summary

Why was this study done?

• Advance care planning (ACP) has been widely advocated as an approach to support patients, relatives, and healthcare professionals in reflecting on and discussing patients’ preferences and to adapt care and treatment accordingly.

• There is little evidence of its effectiveness in relation to patients with advanced cancer in Europe.

What did the researchers do and find?

• We conducted a study in 23 hospitals in 6 European countries, including 1,117 patients with advanced lung or colorectal cancer.

• Depending on the hospital where they were treated, they were offered ACP conversations with a certified facilitator or they were offered care as usual.

• Sixty-seven percent of patients considered the ACP conversations helpful, and most patients who took part in the ACP conversations appointed a relative who could represent their interests if they would not be able to do so themselves.

• Thirty-seven percent of patients in the intervention group completed a form to record their preferences for future care.

• We found that ACP conversations did not have an impact on patients’ quality of life, coping, or involvement in decision-making processes; patients who had had ACP conversations more often received specialist palliative care.

What do these findings mean?

• The findings of the ACTION study did not provide evidence to support the use of a structured ACP intervention to improve the quality of life of patients affected by advanced lung or colorectal cancer.

• There is some evidence that patients taking part in ACP conversations were more likely to receive palliative care, and more likely to have their documented preferences recorded in their medical records.

• Further research is required to establish how patients can best be supported to formulate and, if they wish, to document their preferences for future care.