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      X-ray micro-computed tomography ( μCT): an emerging opportunity in parasite imaging

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          Abstract

          X-ray micro-computed tomography ( μCT) is a technique which can obtain three-dimensional images of a sample, including its internal structure, without the need for destructive sectioning. Here, we review the capability of the technique and examine its potential to provide novel insights into the lifestyles of parasites embedded within host tissue. The current capabilities and limitations of the technology in producing contrast in soft tissues are discussed, as well as the potential solutions for parasitologists looking to apply this technique. We present example images of the mouse whipworm Trichuris muris and discuss the application of μCT to provide unique insights into parasite behaviour and pathology, which are inaccessible to other imaging modalities.

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          Most cited references 55

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          Drug resistance in veterinary helminths.

          At present, there is no effective alternative to chemical control of parasitic helminths where livestock are grazed intensively. Resistance to anthelmintics has become a major problem in veterinary medicine, and threatens both agricultural income and animal welfare. The molecular and biochemical basis of this resistance is not well understood. The lack of reliable biological and molecular tests means that we are not able to follow the emergence and spread of resistance alleles and clinical resistance as well as we need. This review summarizes some of the recent findings on resistance mechanisms, puts forward some recommendations for limiting its impact and suggests some priorities for research in this area.
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            The Reconstruction of a Three-Dimensional Structure from Projections and its Application to Electron Microscopy

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              Quantitative X-ray tomography

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                Author and article information

                Journal
                Parasitology
                Parasitology
                PAR
                Parasitology
                Cambridge University Press (Cambridge, UK )
                0031-1820
                1469-8161
                June 2018
                28 November 2017
                : 145
                : 7
                : 848-854
                Affiliations
                [1 ]School of Materials, The University of Manchester , Oxford Road, Manchester M13 9PL, UK
                [2 ]School of Biological Sciences, The University of Manchester , Oxford Road, Manchester M13 9PL, UK
                Author notes
                Author for correspondence: James D. B. O'Sullivan, E-mail: james.osullivan-4@ 123456postgrad.manchester.ac.uk
                [*]

                Senior authors

                Article
                S0031182017002074 00207
                10.1017/S0031182017002074
                6088774
                29179788
                © Cambridge University Press 2017

                This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.

                Page count
                Figures: 4, References: 70, Pages: 7
                Product
                Categories
                Review Article

                Parasitology

                x-ray tomography, pathology, microscopy, helminth

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