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      Aspirin Sensitivity: The Role for Aspirin Challenge and Desensitization in Postmyocardial Infarction Patients

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          Abstract

          Aspirin is one of the world’s most commonly used medications and its use benefits many diverse conditions. Adverse reactions, however, are relatively common as well. Hypersensitivity to aspirin can be manifested as acute asthma, urticaria and/or angioedema, or a systemic anaphylactoid reaction. We report 3 cases in whom aspirin was indicated for secondary prophylaxis of myocardial infarction but in whom a remote history of an untoward reaction to it prevented its initial use. These patients all underwent further evaluation of their pulmonary and allergic history and all 3 were challenged with aspirin. Two patients were found not to be sensitive and started on aspirin, the other had a classic asthmatic reaction to the drug and was successfully desensitized to aspirin allowing for its use.

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          An expanded profile of cutaneous reactions to nonsteroidal anti-inflammatory drugs. Reports to a specialty-based system for spontaneous reporting of adverse reactions to drugs

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            Author and article information

            Journal
            CRD
            Cardiology
            10.1159/issn.0008-6312
            Cardiology
            S. Karger AG
            0008-6312
            1421-9751
            1999
            June 1999
            18 June 1999
            : 91
            : 1
            : 8-13
            Affiliations
            Divisions of aPulmonary, Allergy and Critical Care Medicine and bCardiovascular Medicine, University of Massachusetts Medical School, Worcester, Mass., USA
            Article
            6871 Cardiology 1999;91:8–13
            10.1159/000006871
            10393393
            2a68ebce-f0b9-45e8-8d95-a5f8d61fa520
            © 1999 S. Karger AG, Basel

            Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

            History
            Page count
            Figures: 1, Tables: 4, References: 27, Pages: 6
            Categories
            General Cardiology

            General medicine,Neurology,Cardiovascular Medicine,Internal medicine,Nephrology
            Hypersensitivity,Aspirin,Allergy,Myocardial infarction,Cardiovascular disease,Asthma,Urticaria,Angioedema

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