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Abstract

Introduction: Hepatitis C virus (HCV) infection is a major complex public health problem. Different resources have proved that healthcare workers more than the general population are at a risk of infection. Therefore, medical field students, due to the future occupational hazards, are included in the risk group. Aim: The purpose of the study was to evaluate the level of knowledge, public and individual risk perception, and behavioral intention about HCV, among medical sciences students of the Isfahan University of Medical Sciences. Settings and Design: This is a descriptive–analytical study that was conducted among 457 students of the Medical Sciences in the Isfahan University of Medical Sciences. Materials and Methods: The data was collected using a questionnaire. Sampling was done randomly. Statistical Analysis Used: The data was analyzed using the SPSS18 software and statistical tests of Pearson, Spearman, T- test, and the analysis of variance (ANOVA); P < 0.05 was considered significant. Results: Four hundred and fifty-seven students (41.8% male and 58.2% female) in 29 fields of study (six categories) participated in this research. The mean age was 21.55 ± 2.6 years. The mean and standard deviations of the students’ knowledge was 3.71 ± 2.9 (out of 8), and the behavioral intention to accruing information and performance of preventive actions related to HCV was 11.52 ± 3.16 (out of 20). Public risk perception was 20.1 ± 3.5 (out of 30); and personal risk perception was 6.96 ± 1.8 (out of 10). The ANOVA test showed that public perception of the risk among students of different academic fields was different (F = 1.52, P < 0.05). Conclusions: According to the low knowledge of students of Medical Sciences in the Isfahan University of Medical Sciences about HCV, it was recommended that the University Policymakers design an educational intervention about it, in order to minimize the chances of being infected.

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Occupational exposure to blood and risk of bloodborne virus infection among health care workers in rural north Indian health care settings.

Damien Jolley, M. Thomas, Michelle Kermode … (2005)

Approximately 3 million health care workers (HCWs) experience percutaneous exposure to bloodborne viruses (BBVs) each year. This results in an estimated 16,000 hepatitis C, 66,000 hepatitis B, and 200 to 5000 human immunodeficiency virus (HIV) infections annually. More than 90% of these infections are occurring in low-income countries, and most are preventable. Several studies report the risks of occupational BBV infection for HCWs in high-income countries where a range of preventive interventions have been implemented. In contrast, the situation for HCWs in low-income countries is not well documented, and their health and safety remains a neglected issue. To describe the extent of occupational exposure to blood and the risk of BBV infection among a group of HCWs in rural north India. A cross-sectional survey of HCWs from 7 rural health settings gathered data pertaining to occupational exposure to blood and a range of other relevant variables (eg, demographic information, compliance with Universal Precautions, perception of risk, knowledge of BBVs). A mass action model was used to estimate the risk of occupational BBV infection for these HCWs over a 10-year period. A total of 266 HCWs returned questionnaires (response rate, 87%). Sixty-three percent reported at least 1 percutaneous injury (PI) in the last year (mean no. = 2.3) and 73% over their working lifetime (mean no. = 4.2). Predictors of PI during the last year were hospital site, job category, perception of risk, and compliance with Universal Precautions. The high level of occupational exposure to blood found among this group of rural north Indian HCWs highlights the urgent need for interventions to enhance their occupational safety to prevent unnecessary nosocomial transmission of BBVs.

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Vaccination for hepatitis C virus: closing in on an evasive target.

Eleanor Barnes, Paul Klenerman, John Halliday (2011)

Hepatitis C virus (HCV) infects more than 170 million people globally and is a leading cause of liver cirrhosis, transplantation and hepatocellular carcinoma. Current gold-standard therapy often fails, has significant side effects in many cases and is expensive. No vaccine is currently available. The fact that a significant proportion of infected people spontaneously control HCV infection in the setting of an appropriate immune response suggests that a vaccine for HCV is a realistic goal. A comparative analysis of infected people with distinct clinical outcomes has enabled the characterization of many important innate and adaptive immune processes associated with viral control. It is clear that a successful HCV vaccine will need to exploit and enhance these natural immune defense mechanisms. New HCV vaccine approaches, including peptide, recombinant protein, DNA and vector-based vaccines, have recently reached Phase I/II human clinical trials. Some of these technologies have generated robust antiviral immunity in healthy volunteers and infected patients. The challenge now is to move forward into larger at-risk or infected populations to truly test efficacy.

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The association between knowledge of hepatitis C virus status and risk behaviors in injection drug users.

Carol Kwiatkowski, Rachell E Booth, Karen F. Corsi (2002)

The three primary objectives of this study were (1) to document the prevalence of the hepatitis C virus (HCV) and awareness of one's status in a sample of street-recruited injection drug users (IDUs); (2) to compare the drug use and HCV risk behaviors of IDUs who reported that they were HCV infected with those who were unaware of their status and subsequently tested positive for HCV antibodies; and (3) to assess associations between risk factors and HCV status by comparing those who tested positive with those who tested negative. IDUs responded to structured interview questions assessing HCV risk behaviors and were offered a free HCV test. Subjects were recruited through street outreach in Denver, CO, USA. Participants were current, out-of-treatment IDUs. A modified version of the Risk Behavior Assessment (RBA) and HCV test results were used. Of the 197 participants, 20% had been diagnosed previously with HCV. Of those who did not know their status, 61% tested positive for HCV antibodies. Those who knew they were positive had been injecting longer but engaged in fewer HCV risk behaviors than those who did not know their status. Compared to those who tested negative, those who tested positive were more likely to be male, non-white and older. They also had been injecting longer, were more likely to use heroin and/or crack cocaine and consumed more alcohol. In this study, a very large proportion of injection drug users who had hepatitis C were unaware of it, and they were engaging in more risk behaviors than those who were aware of their positive status. Risk factors associated with positive HCV status were identified so that those who are most at-risk for HCV might be targeted for testing and subsequent prevention or care.