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      Fetal alcohol syndrome and secondary schizophrenia: a unique neuropathologic study.

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          Abstract

          We report the unique neuropathologic study of an adult brain of a patient with fetal alcohol syndrome who developed the well-recognized complication of schizophrenia in adolescence. The major finding was asymmetric formation of the lateral temporal lobes, with marked enlargement of the right superior temporal gyrus, suggesting that alcohol is preferentially toxic to temporal lobe patterning during gestation. Critical maturational changes unique to adolescence can unmask psychotic symptomatology mediated by temporal lobe pathology that has been clinically dormant since birth. Elucidating the neuropathologic basis of the secondary psychiatric disorders in fetal alcohol syndrome can help provide insight into their putative developmental origins.

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          Author and article information

          Journal
          J. Child Neurol.
          Journal of child neurology
          SAGE Publications
          1708-8283
          0883-0738
          Apr 2015
          : 30
          : 5
          Affiliations
          [1 ] Department of Pathology, Sanford Health, Sioux Falls, SD, USA.
          [2 ] Department of Pathology, MaineGeneral Health, Augusta, MA, USA.
          [3 ] Department of Pathology, Boston Children's Hospital and Harvard Medical School, MA, USA.
          [4 ] Department of Pathology, Boston Children's Hospital and Harvard Medical School, MA, USA Hannah.Kinney@Childrens.Harvard.edu.
          Article
          0883073814520976
          10.1177/0883073814520976
          24563476
          2a82898e-57f6-4526-afc4-7c13204c64cd
          History

          areal patterning,schizophrenia,superior temporal gyrus

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