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      Steroid Therapy in IgA Nephropathy: A Retrospective Study in Heavy Proteinuric Cases

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          29 patients with IgA nephropathy whose proteinuria persisted at a level of 2.0 g/day or more and who received prednisolone treatment for 1–3 years were retrospectively evaluated on their clinical courses. 13 of 14 patients with renal dysfunction of less than 70 ml/min in initial creatinine clearance (C<sub>cr</sub>) values subsequently entered a progressive course during a follow-up period of 47 months, leading to end-stage renal failure in 8 cases. On the other hand, only 1 of the other 15 patients with preserved renal function of 70 ml/min or more ended up with end-stage renal failure during a follow-up period of 74 months, although 7 underwent a progressive course. Three patients in the latter group experienced a prominent reduction in proteinuria to less than 1.0 g/day and maintained renal function. Meanwhile, the steroid group of moderate proteinuric patients with a creatinine clearance greater than 70 ml/min had a benign course, while the nonsteroid group had an unfavorable one. These results suggest that steroid therapy in IgA nephropathy may be able to stabilize a progressive course, especially in the early stage of the disease, although, because they come from an uncontrolled study, a definite conclusion cannot be drawn.

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          Author and article information

          S. Karger AG
          09 December 2008
          : 48
          : 1
          : 12-17
          Department of Medicine, Kitasato University School of Medicine, Sagamihara, Japan
          184861 Nephron 1988;48:12–17
          © 1988 S. Karger AG, Basel

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          Page count
          Pages: 6
          Original Paper

          Cardiovascular Medicine, Nephrology

          Heavy proteinuria, Steroid therapy, IgA nephropathy


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