In this paper we present a system using Semantic Web by which applications can be effectively constructed for clinical research purposes. We are aware of the immense difficulties and variations involved in clinical research applications. With a purpose of mitigating some of these difficulties in the process of developing clinical research applications we are presenting an approach for building information systems based on Semantic Web. We have developed a working prototype using C-Map tools leveraging the underlying principles of Abstract Software Design Framework to convert domain knowledge into machine-actable information.