Introduction: Stress among students is a major concern in tertiary education. This study determined the predominance source of stress among health sciences students in Malaysia. Methodology: Medical Student Stressor Questionnaire (MSSQ) represents 40 events possible sources of stress. was distributed to 248 health science students. Result and discussion: The MSSQ showed satisfactory level of psychometric property in the health science students. The main source of stress was the academic related stressor Conclusion: Academic requirement is the major stressor for the students. This finding is consistent with the literature and appropriate measures should be sought to prevent its unwanted consequences.