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      PHENIX: a comprehensive Python-based system for macromolecular structure solution

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          Abstract

          The PHENIX software for macromolecular structure determination is described.

          Abstract

          Macromolecular X-ray crystallography is routinely applied to understand biological processes at a molecular level. How­ever, significant time and effort are still required to solve and complete many of these structures because of the need for manual interpretation of complex numerical data using many software packages and the repeated use of interactive three-dimensional graphics. PHENIX has been developed to provide a comprehensive system for macromolecular crystallo­graphic structure solution with an emphasis on the automation of all procedures. This has relied on the development of algorithms that minimize or eliminate subjective input, the development of algorithms that automate procedures that are traditionally performed by hand and, finally, the development of a framework that allows a tight integration between the algorithms.

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          Author and article information

          Affiliations
          [a ]Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
          [b ]Department of Bioengineering, UC Berkeley, CA 94720, USA
          [c ]Department of Haematology, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Cambridge CB2 0XY, England
          [d ]Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA
          [e ]Los Alamos National Laboratory, Los Alamos, NM 87545, USA
          Author notes
          Correspondence e-mail: pdadams@ 123456lbl.gov
          [‡]

          Current address: GrassRoots Biotechnology, 598 Airport Boulevard, Morrisville, NC 27560, USA.

          Journal
          Acta Crystallogr D Biol Crystallogr
          Acta Cryst. D
          Acta Crystallographica Section D: Biological Crystallography
          International Union of Crystallography
          0907-4449
          1399-0047
          01 February 2010
          22 January 2010
          22 January 2010
          : 66
          : Pt 2 ( publisher-idID: d100200 )
          : 213-221
          2815670
          20124702
          dz5186
          10.1107/S0907444909052925
          ABCRE6 S0907444909052925
          © Adams et al. 2010

          This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.

          Categories
          Research Papers

          Microscopy & Imaging

          phenix, python, macromolecular crystallography, algorithms

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