For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
11
views
16
references
 Top references
cited by
1
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      181
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Hair Loss: Evidence to Thallium Poisoning

      case-report
      Author(s): 1 , 2 , 2 , 3 ,
      Publication date (Electronic):
      Journal: Case Reports in Emergency Medicine
      Publisher: Hindawi

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          In clinical practice, thallium poisoning is very hard to diagnose, because it is a very uncommon disease and its clinical manifestations are extremely complicated. In the present study, we investigated a case of a 53-year-old man who was hospitalized for persistent stabbing pain in the abdomen and lower extremities for 20 days. Physical examination revealed diffuse alopecia of the scalp. The final diagnosis of thallium poisoning was confirmed based on high blood and urine thallium levels. The patient was cured by an oral administration of Prussian blue combined with hemoperfusion and continuous veno-venous hemofiltration.

          Related collections

          Most cited references16

          • Record: found
          • Abstract: found
          • Article: not found

          Thallium Toxicity: General Issues, Neurological Symptoms, and Neurotoxic Mechanisms.

          Sonia Galván-Arzate, Abel Santamaria, Laura Osorio-Rico (2017)
          Thallium (Tl+) is a ubiquitous natural trace metal considered as the most toxic among heavy metals. The ionic ratio of Tl+ is similar to that of potassium (K+), therefore accounting for the replacement of the latter during enzymatic reactions. The principal organelle damaged after Tl+ exposure is mitochondria. Studies on the mechanisms of Tl+ include intrinsic pathways altered and changes in antiapoptotic and proapoptotic proteins, cytochrome c, and caspases. Oxidative damage pathways increase after Tl+ exposure to produce reactive oxygen species (ROS), changes in physical properties of the cell membrane caused by lipid peroxidation, and concomitant activation of antioxidant mechanisms. These processes are likely to account for the neurotoxic effects of the metal. In humans, Tl+ is absorbed through the skin and mucous membranes and then is widely distributed throughout the body to be accumulated in bones, renal medulla, liver, and the Central Nervous System. Given the growing relevance of Tl+ intoxication, in recent years there is a notorious increase in the number of reports attending Tl+ pollution in different countries. In this sense, the neurological symptoms produced by Tl+ and its neurotoxic effects are gaining attention as they represent a serious health problem all over the world. Through this review, we present an update to general information about Tl+ toxicity, making emphasis on some recent data about Tl+ neurotoxicity, as a field requiring attention at the clinical and preclinical levels.
          Article 0 comments Cited 25 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            Toxicity and pollution potential of thallium

            V Zitko (1975)
            Article 0 comments Cited 13 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Thallium poisoning: emphasis on early diagnosis and response to haemodialysis.

              U. K. Misra, J. Kalita, R. K. Yadav … (2003)
              Thallium poisoning is known for its diverse manifestations and these can delay the diagnosis if a clear history of poisoning is not forthcoming. A 42 year old man presented on the third day of illness with flaccid quadriparesis and paresthesia, which were confused with Guillain-Barré syndrome. Because of associated loose motions, skin lesions, and liver and kidney dysfunction arsenic poisoning was considered. In the second week he developed ophthalmoplegia, nystagmus, and neck tremor and later developed alopecia, and thallium poisoning was suspected. His serum thallium level on the 18th day of illness was 40 980 micro g/ml. He was subjected to haemodialysis, potassium supplementation, laxatives, and B complex supplementation. He showed significant improvement after haemodialysis and at three months he was able to walk with support. At six months of follow up he was independent for activities of daily living. Severe paresthesia, ophthalmoplegia, cerebellar and extrapyramidal signs, and alopecia are highly suggestive of thallium poisoning. Haemodialysis may be effective even in the third week of poisoning.
              Article 0 comments Cited 13 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                Lijuan Sheng:
                ORCID: http://orcid.org/0000-0001-5768-1204
                Journal
                Journal ID (nlm-ta): Case Rep Emerg Med
                Journal ID (iso-abbrev): Case Rep Emerg Med
                Journal ID (publisher-id): CRIEM
                Title: Case Reports in Emergency Medicine
                Publisher: Hindawi
                ISSN (Print): 2090-648X
                ISSN (Electronic): 2090-6498
                Publication date Collection: 2018
                Publication date (Electronic): 26 June 2018
                Volume: 2018
                Electronic Location Identifier: 1313096
                Affiliations
                1Department of Emergency, The Second Xiangya Hospital, Central South University, China
                2Department of Emergency, The Changsha Central Hospital, Changsha, China
                3Department of Neurology, The Second Xiangya Hospital, Central South University, China
                Author notes

                Academic Editor: Kalpesh Jani

                Author information
                http://orcid.org/0000-0001-5768-1204
                Article
                DOI: 10.1155/2018/1313096
                PMC ID: 6038659
                SO-VID: 2a90f3df-ff53-489c-9b52-f95726bc27f3
                Copyright © Copyright © 2018 Guifang Yang et al.
                License:

                This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 8 December 2017
                Date revision received : 13 May 2018
                Date accepted : 4 June 2018
                Categories
                Subject: Case Report

                ScienceOpen disciplines: Emergency medicine & Trauma
                Data availability:
                ScienceOpen disciplines: Emergency medicine & Trauma

                Comments

                Comment on this article

                scite_

                Similar content181

                See all similar

                Cited by1

                See all cited by

                Most referenced authors132

                See all reference authors