Wegener’s Granulomatosis Limited to the Kidney as a Masslike Lesion

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Abstract

We report on a 45-year-old female who presented with end-stage renal disease due to Wegener’s granulomatosis limited to the kidneys. Ultrasonography and computed tomography revealed a masslike expansion involving the upper pole of an otherwise small right kidney. Histopathology of a nephrectomy specimen revealed cystic dilatation of renal tubules and active lesions of Wegener’s granulomatosis in the upper pole. The lower part of the kidney showed atrophic changes. Wegener’s granulomatosis presenting as a renal mass is extremely rare. Only 3 cases have been previously reported in the literature. Wegener’s granulomatosis only limited to the kidney is also rare. A brief review of 23 previously reported cases who initially presented with renal disease is presented. All but 2 patients subsequently manifested extrarenal lesions. Our patient continues to be free of any extrarenal involvement 18 months following presentation, although subsequent development of extrarenal lesions cannot be ruled out.

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Journal

Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1994

Publication date (Print): 1994

Publication date (Electronic): 17 December 2008

Volume: 68

Issue: 4

Pages: 500-504

Affiliations

Departments of ^aMedicine, ^bPathology and ^cRadiology, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

Article

Publisher ID: 188314 Other ID: Nephron 1994;68:500–504

DOI: 10.1159/000188314

PubMed ID: 7870236

SO-VID: 2a9266b7-8277-4104-8b95-c2369b1b880b

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date accepted : 19 January 1994

Page count

Pages: 5

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