Blog
About

0
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Estimation of Infarct Size by Creatine Kinase

      a , b , a

      Cardiology

      S. Karger AG

      Infarct size, Acute myocardial infarction, Creatine kinase

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Serum samples for creatine kinase (CK) activity were obtained serially during 48 h in patients with acute myocardial infarction (AMI) diagnosed according to conventional criteria. Infarct size was estimated as peak enzyme value (CK<sub>max</sub>), area under the enzyme curve measured planimetrically (AUC) and was also calculated according to Sobel et al. (IS) by a computer. In 16 patients with enzyme curves judged to fit the computer method, there was a good correlation between AUC and IS (r = 0.97), between AUC and CK<sub>max</sub> (r = 0.99) and accordingly also between IS and CK<sub>max</sub> (r = 0.96). The results from 34 consecutive patients with AMI were plotted in the graphs obtained from the 16 patients with ‘ideal’ enzyme curves. 15 % fell outside ± 2 SD when AUC was correlated to IS, 3 % when AUC was correlated to CK<sub>max</sub> and 12 % when IS was correlated to CK<sub>max</sub>. There was no difference between enzyme curves falling outside or within ± 2 SD. The explanation for the high correlation between these three methods may be that all these ways of estimating infarct size are imprecise and only give a rough estimation of the size of the infarction.

          Related collections

          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1981
          1981
          07 November 2008
          : 68
          : 4
          : 201-205
          Affiliations
          a Department of Medicine, Karolinska Hospital, and bDepartment of Medicine, Huddinge Hospital, Karolinska Institute, Stockholm, Sweden
          Article
          173283 Cardiology 1981;68:201–205
          10.1159/000173283
          7326667
          © 1981 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 5
          Categories
          Original Paper

          Comments

          Comment on this article