T ^-786→C Polymorphism of the Endothelial Nitric Oxide Synthase Gene Influences the Progression of Renal Disease

Abstract

Background/Aims: Polymorphism of the endothelial nitric oxide synthase (ecNOS) gene may be involved in renal disease. Recently, T^-786→C polymorphism affecting ecNOS gene transcription has been reported. To clarify the role of T^-786→C polymorphism in renal disease, we investigated hemodialysis patients and healthy controls for this polymorphism and we compared its frequency with that of intron 4 polymorphism in the hemodialysis patients. Methods: The subjects were 252 patients who had been on hemodialysis for less than 2 years (168 with nondiabetic nephropathy and 84 with diabetic nephropathy) and 187 healthy controls. T^-786→C polymorphism was detected using polymerase chain reaction-restriction fragment length polymorphism analysis. Results: The frequencies of the T/ C and C/ C genotypes were significantly higher in the nondiabetic hemodialysis patients than in the controls (odds ratio 1.41; 95% Cl 1.03–2.00), and were also significantly higher in the diabetic hemodialysis patients than in the controls (odds ratio 1.56; 95% Cl 1.02–2.41). In addition, T^-786→C polymorphism and intron 4 polymorphism showed strong linkage disequilibrium. Conclusion: T^-786→C polymorphism may be involved in the progression of both nondiabetic and diabetic nephropathy, along with intron 4 polymorphism.

Journal

Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 2002

Publication date (Print): August 2002

Publication date (Electronic): 15 July 2002

Volume: 91

Issue: 4

Pages: 747-751

Affiliations

Second Department of Internal Medicine, Hiroshima University School of Medicine, Hiroshima, Japan

Article

Publisher ID: 65041 Other ID: Nephron 2002;91:747–751

DOI: 10.1159/000065041

PubMed ID: 12138283

Copyright statement: © 2002 S. Karger AG, Basel

License:

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Page count

Figures: 1, Tables: 2, References: 19, Pages: 5

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Categories

Subject: Short Communication