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      Melatonin sensitizes H1975 non-small-cell lung cancer cells harboring a T790M-targeted epidermal growth factor receptor mutation to the tyrosine kinase inhibitor gefitinib.

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          Abstract

          The use of tyrosine kinase inhibitors (TKIs) to target active epidermal growth factor receptor (EGFR)-harbouring mutations has been effective in patients with advanced non-small-cell lung cancer (NSCLC). However, the use of TKIs in NSCLS patients with somatic EGFR mutations, particularly T790M, causes drug resistance. Thus, in the present study, we investigated overcoming resistance against the TKI gefitinib by combination treatment with melatonin in H1975 NSCLC cells harbouring the T790M somatic mutation.

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          Author and article information

          Journal
          Cell. Physiol. Biochem.
          Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
          S. Karger AG
          1421-9778
          1015-8987
          2014
          : 34
          : 3
          Affiliations
          [1 ] College of Korean Medicine, Kyung Hee University, Seoul, South Korea.
          Article
          000366305
          10.1159/000366305
          25199820
          2a9dc921-6cd5-492c-bbf4-946af275e7cb
          History

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