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      Testicular Protein Synthesis during the Response to Subtoxic Levels of Cadmium

      ,

      Hormone Research in Paediatrics

      S. Karger AG

      Cadmium toxicity, Testes, Protein synthesis

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          Abstract

          Male rats received one injection of a ‘subtoxic’ amount of Cd<sup>2+</sup> (9.2 µmol/kg body weight) as cadmium chloride and the testes were removed 24 h later. Homogenate fractions of testes that had been freed of ribosomes were tested for their activity in cell-free protein-synthesizing systems using excess exogenous rat liver ribosomes and mRNA. A marked decrease in the incorporation of free [<sup>14</sup>C]-phenylalanine into peptide was observed with the testes preparations from the cadmium-treated rats. The results indicated that about half of the effect of cadmium was due to decreased aminoacyl-tRNA synthetase activity and the other half was due to decreased binding of [<sup>14</sup>C]-phenylalanyl-tRNA to ribosomes. The results are discussed relative to the contrasting results obtained in kidney and liver preparations.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1981
          1981
          25 November 2008
          : 14
          : 1
          : 56-69
          Affiliations
          Department of Biology, York University, Downsview (Toronto), Ont., Canada
          Article
          179357 Horm Res 1981;14:56–69
          10.1159/000179357
          7262840
          © 1981 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 14
          Categories
          Original Paper

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