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      Testicular Protein Synthesis during the Response to Subtoxic Levels of Cadmium


      Hormone Research in Paediatrics

      S. Karger AG

      Cadmium toxicity, Testes, Protein synthesis

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          Male rats received one injection of a ‘subtoxic’ amount of Cd<sup>2+</sup> (9.2 µmol/kg body weight) as cadmium chloride and the testes were removed 24 h later. Homogenate fractions of testes that had been freed of ribosomes were tested for their activity in cell-free protein-synthesizing systems using excess exogenous rat liver ribosomes and mRNA. A marked decrease in the incorporation of free [<sup>14</sup>C]-phenylalanine into peptide was observed with the testes preparations from the cadmium-treated rats. The results indicated that about half of the effect of cadmium was due to decreased aminoacyl-tRNA synthetase activity and the other half was due to decreased binding of [<sup>14</sup>C]-phenylalanyl-tRNA to ribosomes. The results are discussed relative to the contrasting results obtained in kidney and liver preparations.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          25 November 2008
          : 14
          : 1
          : 56-69
          Department of Biology, York University, Downsview (Toronto), Ont., Canada
          179357 Horm Res 1981;14:56–69
          © 1981 S. Karger AG, Basel

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          Pages: 14
          Original Paper


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