45
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Nanoparticle vaccines.

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Nanotechnology increasingly plays a significant role in vaccine development. As vaccine development orientates toward less immunogenic "minimalist" compositions, formulations that boost antigen effectiveness are increasingly needed. The use of nanoparticles in vaccine formulations allows not only improved antigen stability and immunogenicity, but also targeted delivery and slow release. A number of nanoparticle vaccines varying in composition, size, shape, and surface properties have been approved for human use and the number of candidates is increasing. However, challenges remain due to a lack of fundamental understanding regarding the in vivo behavior of nanoparticles, which can operate as either a delivery system to enhance antigen processing and/or as an immunostimulant adjuvant to activate or enhance immunity. This review provides a broad overview of recent advances in prophylactic nanovaccinology. Types of nanoparticles used are outlined and their interaction with immune cells and the biosystem are discussed. Increased knowledge and fundamental understanding of nanoparticle mechanism of action in both immunostimulatory and delivery modes, and better understanding of in vivo biodistribution and fate, are urgently required, and will accelerate the rational design of nanoparticle-containing vaccines.

          Related collections

          Author and article information

          Journal
          Vaccine
          Vaccine
          Elsevier BV
          1873-2518
          0264-410X
          Jan 09 2014
          : 32
          : 3
          Affiliations
          [1 ] The University of Queensland, Australian Institute for Bioengineering and Nanotechnology, St. Lucia QLD 4072, Australia.
          [2 ] The University of Queensland, Queensland Alliance for Agriculture and Food Innovation, St. Lucia QLD 4072, Australia.
          [3 ] The University of Queensland, Australian Institute for Bioengineering and Nanotechnology, St. Lucia QLD 4072, Australia. Electronic address: a.middelberg@uq.edu.au.
          Article
          S0264-410X(13)01631-9
          10.1016/j.vaccine.2013.11.069
          24295808
          2abcd6ee-a06e-4906-a999-224b6fbc34dd
          Copyright © 2013 The Authors. Published by Elsevier Ltd.. All rights reserved.
          History

          Adjuvant,Nanoparticle,Nanotechnology,Nanovaccinology,Vaccine

          Comments

          Comment on this article