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      Isolation of salicin derivatives from Homalium cochinchinensis and their antiviral activities.

      Journal of Natural Products

      Anti-HIV Agents, chemistry, isolation & purification, pharmacology, Antiviral Agents, Benzyl Alcohols, Flacourtiaceae, Glucosides, Medicine, Traditional, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Plant Bark, Plant Leaves, Plant Roots, Plants, Medicinal

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          Abstract

          The chemical constituents of Homalium cochinchinensis were examined. From the root bark, in addition to the previously reported cochinolide and its beta-glucopyranoside, cochinchiside A (1) and tremulacinol (4) were isolated together with three known compounds [benzoic acid, tremulacin (2), and tremuloidin (3)]. From the leaves, cochinchiside B (5) was isolated as new compound. The structures of the new compounds (1, 4, 5) were determined by spectroscopic and/or chemical methods. Antiviral testing of compounds 2-5 against HSV-1 and HSV-2 showed that tremulacin (2) and cochinchiside B (5) were weakly active. Tremulacin (2) was also weakly active against HIV-1.

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          Journal
          15104498
          10.1021/np034052o

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