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      Neurotrophins: roles in neuronal development and function.

      1 ,
      Annual review of neuroscience
      Annual Reviews

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          Abstract

          Neurotrophins regulate development, maintenance, and function of vertebrate nervous systems. Neurotrophins activate two different classes of receptors, the Trk family of receptor tyrosine kinases and p75NTR, a member of the TNF receptor superfamily. Through these, neurotrophins activate many signaling pathways, including those mediated by ras and members of the cdc-42/ras/rho G protein families, and the MAP kinase, PI-3 kinase, and Jun kinase cascades. During development, limiting amounts of neurotrophins function as survival factors to ensure a match between the number of surviving neurons and the requirement for appropriate target innervation. They also regulate cell fate decisions, axon growth, dendrite pruning, the patterning of innervation and the expression of proteins crucial for normal neuronal function, such as neurotransmitters and ion channels. These proteins also regulate many aspects of neural function. In the mature nervous system, they control synaptic function and synaptic plasticity, while continuing to modulate neuronal survival.

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          Author and article information

          Journal
          Annu Rev Neurosci
          Annual review of neuroscience
          Annual Reviews
          0147-006X
          0147-006X
          2001
          : 24
          Affiliations
          [1 ] Department of Pathology, University of California, San Francisco, California 94143, USA. ejhuang@itsa.ucsf.edu
          Article
          24/1/677 NIHMS112782
          10.1146/annurev.neuro.24.1.677
          2758233
          11520916
          2aef2387-d071-461a-b7cf-fdb681028190
          History

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