Rituximab for childhood-onset, complicated, frequently relapsing nephrotic syndrome or steroid-dependent nephrotic syndrome: a multicentre, double-blind, randomised, placebo-controlled trial.

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Abstract

Rituximab could be an effective treatment for childhood-onset, complicated, frequently relapsing nephrotic syndrome (FRNS) and steroid-dependent nephrotic syndrome (SDNS). We investigated the efficacy and safety of rituximab in patients with high disease activity.

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Journal

Journal ID (iso-abbrev): Lancet

Title: Lancet (London, England)

ISSN (Electronic): 1474-547X

ISSN (Print): 0140-6736

Publication date (Electronic): Oct 4 2014

Volume: 384

Issue: 9950

Affiliations

[1 ] Department of Pediatrics, Kobe University Graduate School of Medicine, Chuo-ku, Kobe, Japan. Electronic address: iijima@med.kobe-u.ac.jp.

[2 ] Division for Clinical Trials, Department of Development Strategy, Center for Social and Clinical Research, National Research Institute for Child Health and Development, National Center for Child Health and Development, Setagaya-ku, Tokyo, Japan.

[3 ] Department of Pediatrics, Kobe University Graduate School of Medicine, Chuo-ku, Kobe, Japan.

[4 ] Department of Health Policy, Center for Social and Clinical Research, National Research Institute for Child Health and Development, National Center for Child Health and Development, Setagaya-ku, Tokyo, Japan.

[5 ] Department of General Pediatrics and Interdisciplinary Medicine, National Center for Child Health and Development, Setagaya-ku, Tokyo, Japan.

[6 ] Department of Nephrology and Rheumatology, National Center for Child Health and Development, Setagaya-ku, Tokyo, Japan.

[7 ] Department of Pediatrics, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan.

[8 ] Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Shikata-cho, Okayama, Japan.

[9 ] Department of Pediatrics, Wakayama Medical University, Wakayama, Japan.

[10 ] Department of Pediatrics, Juntendo University Nerima Hospital, Nerima-ku, Tokyo, Japan.

[11 ] Department of Pediatrics, Surugadai Nihon University Hospital, Chiyoda-ku, Tokyo, Japan.

[12 ] Department of Nephrology, Hyogo Prefectural Kobe Children's Hospital, Suma-Ku, Kobe, Japan.

[13 ] Department of Nephrology, Tokyo Metropolitan Children's Medical Center, Fuchu, Japan.

[14 ] Chuo University, Bunkyo-ku, Tokyo, Japan.

Article

Publisher Item ID: S0140-6736(14)60541-9

DOI: 10.1016/S0140-6736(14)60541-9

PubMed ID: 24965823

SO-VID: 2b07d81c-dd02-4550-85fd-d6d9b0702cb4

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