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      Rituximab for childhood-onset, complicated, frequently relapsing nephrotic syndrome or steroid-dependent nephrotic syndrome: a multicentre, double-blind, randomised, placebo-controlled trial.

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          Abstract

          Rituximab could be an effective treatment for childhood-onset, complicated, frequently relapsing nephrotic syndrome (FRNS) and steroid-dependent nephrotic syndrome (SDNS). We investigated the efficacy and safety of rituximab in patients with high disease activity.

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          Author and article information

          Journal
          Lancet
          Lancet (London, England)
          1474-547X
          0140-6736
          Oct 4 2014
          : 384
          : 9950
          Affiliations
          [1 ] Department of Pediatrics, Kobe University Graduate School of Medicine, Chuo-ku, Kobe, Japan. Electronic address: iijima@med.kobe-u.ac.jp.
          [2 ] Division for Clinical Trials, Department of Development Strategy, Center for Social and Clinical Research, National Research Institute for Child Health and Development, National Center for Child Health and Development, Setagaya-ku, Tokyo, Japan.
          [3 ] Department of Pediatrics, Kobe University Graduate School of Medicine, Chuo-ku, Kobe, Japan.
          [4 ] Department of Health Policy, Center for Social and Clinical Research, National Research Institute for Child Health and Development, National Center for Child Health and Development, Setagaya-ku, Tokyo, Japan.
          [5 ] Department of General Pediatrics and Interdisciplinary Medicine, National Center for Child Health and Development, Setagaya-ku, Tokyo, Japan.
          [6 ] Department of Nephrology and Rheumatology, National Center for Child Health and Development, Setagaya-ku, Tokyo, Japan.
          [7 ] Department of Pediatrics, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan.
          [8 ] Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Shikata-cho, Okayama, Japan.
          [9 ] Department of Pediatrics, Wakayama Medical University, Wakayama, Japan.
          [10 ] Department of Pediatrics, Juntendo University Nerima Hospital, Nerima-ku, Tokyo, Japan.
          [11 ] Department of Pediatrics, Surugadai Nihon University Hospital, Chiyoda-ku, Tokyo, Japan.
          [12 ] Department of Nephrology, Hyogo Prefectural Kobe Children's Hospital, Suma-Ku, Kobe, Japan.
          [13 ] Department of Nephrology, Tokyo Metropolitan Children's Medical Center, Fuchu, Japan.
          [14 ] Chuo University, Bunkyo-ku, Tokyo, Japan.
          Article
          S0140-6736(14)60541-9
          10.1016/S0140-6736(14)60541-9
          24965823
          Copyright © 2014 Elsevier Ltd. All rights reserved.

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