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      Advanced heart failure: a position statement of the Heart Failure Association of the European Society of Cardiology : Advanced heart failure: HFA position statement

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          Effect of Enalapril on Mortality and the Development of Heart Failure in Asymptomatic Patients with Reduced Left Ventricular Ejection Fractions

          New England Journal of Medicine, 327(10), 685-691
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            Depression in heart failure a meta-analytic review of prevalence, intervention effects, and associations with clinical outcomes.

            This article describes a meta-analysis of published associations between depression and heart failure (HF) in regard to 3 questions: 1) What is the prevalence of depression among patients with HF? 2) What is the magnitude of the relationship between depression and clinical outcomes in the HF population? 3) What is the evidence for treatment effectiveness in reducing depression in HF patients? Key word searches of the Medline and PsycInfo databases, as well as reference searches in published HF and depression articles, identified 36 publications meeting our criteria. Clinically significant depression was present in 21.5% of HF patients, and varied by the use of questionnaires versus diagnostic interview (33.6% and 19.3%, respectively) and New York Heart Association-defined HF severity (11% in class I vs. 42% in class IV), among other factors. Combined results suggested higher rates of death and secondary events (risk ratio = 2.1, 95% confidence interval 1.7 to 2.6), trends toward increased health care use, and higher rates of hospitalization and emergency room visits among depressed patients. Treatment studies generally relied on small samples, but also suggested depression symptom reductions from a variety of interventions. In sum, clinically significant depression is present in at least 1 in 5 patients with HF; however, depression rates can be much higher among patients screened with questionnaires or with more advanced HF. The relationship between depression and poorer HF outcomes is consistent and strong across multiple end points. These findings reinforce the importance of psychosocial research in HF populations and identify a number of areas for future study.
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              The 2013 International Society for Heart and Lung Transplantation Guidelines for mechanical circulatory support: executive summary.

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                Author and article information

                Journal
                European Journal of Heart Failure
                Eur J Heart Fail
                Wiley
                13889842
                July 17 2018
                Affiliations
                [1 ]Complexo Hospitalario Universitario A Coruña (CHUAC); Instituto de Investigación Biomédica de A Coruña (INIBIC), CIBERCV, UDC; La Coruña Spain
                [2 ]Cardiology; University of Brescia; Brescia Italy
                [3 ]Department of Medicine, Unit of Cardiology; Karolinska Institute; Stockholm Sweden
                [4 ]Department for Cardiovascular Diseases; University Hospital Center Zagreb, University of Zagreb; Zagreb Croatia
                [5 ]Advocate Heart Institute; Naperville IL USA
                [6 ]Athens University Hospital Attikon; Athens Greece
                [7 ]Department of Cardiology; Rigshospitalet; Copenhagen Denmark
                [8 ]Transplant Unit; Royal Papworth Hospital; Cambridge UK
                [9 ]Department of Cardiology; University Medical Center Utrecht; Utrecht The Netherlands
                [10 ]Transplant Center and De Gasperis Cardio Center; Niguarda Hospital; Milan Italy
                [11 ]Department of Cardiology; Beirut Cardiac Institute; Beirut Lebanon
                [12 ]Jesselson Integrated Heart Center; Shaare Zedek Medical Center; Jerusalem Israel
                [13 ]Department of Internal Medicine II; Medical University of Vienna; Vienna Austria
                [14 ]Department of Cardiology; Ege University Hospital; Izmir Turkey
                [15 ]Heart and Lung Transplant Program; Bologna University Hospital; Bologna Italy
                [16 ]Department of Cardiology and Angiology; Medical School Hannover; Hannover Germany
                [17 ]Heart Failure and Transplant Unit; Onassis Cardiac Surgery Centre; Athens Greece
                [18 ]Department of Cardiac Surgery; University of Heidelberg; Heidelberg Germany
                [19 ]Department of Cardiology of the Clinical Center of Serbia; Belgrade University School of Medicine; Belgrade Serbia
                [20 ]Department of Cardiology; University of Medical Sciences; Poznań Poland
                [21 ]Department of Cardiology; King's College Hospital; London UK
                [22 ]Department of Internal Medicine; Belgrade University School of Medicine and Heart Failure Center, Belgrade University Medical Center; Belgrade Serbia
                [23 ]University Heart Center; University Hospital Zurich; Zurich Switzerland
                Article
                10.1002/ejhf.1236
                2b215427-b7d8-4a1b-92cf-accf34ff0b49
                © 2018

                http://doi.wiley.com/10.1002/tdm_license_1.1

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