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Antepartum dalteparin versus no antepartum dalteparin for the prevention of pregnancy complications in pregnant women with thrombophilia (TIPPS): a multinational open-label randomised trial
Marc A Rodger ,
William M Hague ,
John Kingdom ,
Susan R Kahn ,
Alan Karovitch ,
Mathew Sermer ,
Anne Marie Clement ,
Suzette Coat ,
Wee Shian Chan ,
Joanne Said ,
Evelyne Rey ,
Sue Robinson ,
Rshmi Khurana ,
Christine Demers ,
Michael J Kovacs ,
Susan Solymoss ,
Kim Hinshaw ,
James Dwyer ,
Graeme Smith ,
Sarah McDonald ,
Jill Newstead-Angel ,
Anne McLeod ,
Meena Khandelwal ,
Robert M Silver ,
Gregoire Le Gal ,
Ian A Greer ,
Erin Keely ,
Karen Rosene-Montella ,
Mark Walker ,
Philip S Wells
November 2014
November 2014
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Abstract
Thrombophilias are common disorders that increase the risk of pregnancy-associated
venous thromboembolism and pregnancy loss and can also increase the risk of placenta-mediated
pregnancy complications (severe pre-eclampsia, small-for-gestational-age infants,
and placental abruption). We postulated that antepartum dalteparin would reduce these
complications in pregnant women with thrombophilia.