Shyh-Ren Chiang: Role: Funding acquisitionRole: Project administration
Chia-Yun Lin: Role: Data curationRole: Formal analysisRole: Investigation
Der-Yuan Chen: Role: ConceptualizationRole: MethodologyRole: ResourcesRole: Supervision
Hui-Fang Tsai: Role: Data curationRole: Formal analysisRole: Methodology
Xin-Ci Lin: Role: Data curationRole: Formal analysisRole: Investigation
Tsai-Ching Hsu: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole:
InvestigationRole: Project administrationRole: ResourcesRole: SupervisionRole: Writing
– original draft
Bor-Show Tzang:
ORCID: http://orcid.org/0000-0003-0140-9943
Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole:
Project administrationRole: ResourcesRole: Writing – original draft
Heinz Fehrenbach: Role: Editor
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
14
May
2019
Publication date Collection: 2019
Volume: 14
Issue: 5
Electronic Location Identifier: e0216799
Affiliations
[1
]
Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan, R.O.C
[2
]
Department of General Science, Chia Nan University of Pharmacy and Science, Tainan,
Taiwan, R.O.C
[3
]
Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University,
Taichung, Taiwan, R.O.C
[4
]
Rheumatology and Immunology Center, China Medical University Hospital, Taichung, Taiwan,
R.O.C
[5
]
Rheumatic Diseases Research Center, Department of Medical Research, China Medical
University Hospital, Taichung, Taiwan, R.O.C
[6
]
School of Medicine, China Medical University, Taichung, Taiwan, R.O.C
[7
]
Department of Medical Laboratory and Biotechnology, Chung Shan Medical University,
Taiwan, R.O.C
[8
]
Clinical Laboratory, Chung Shan Medical University Hospital, Taichung, Taiwan, R.O.C
[9
]
Immunology Research Center, Chung Shan Medical University, Taichung, Taiwan, R.O.C
[10
]
Department of Biochemistry, School of Medicine, Chung Shan Medical University, Taichung,
Taiwan, R.O.C
Forschungszentrum Borstel Leibniz-Zentrum fur Medizin und Biowissenschaften, GERMANY
Author notes
Competing Interests: The authors have declared that no competing interests exist.
Author information
Article
Publisher ID:
PONE-D-18-33628
DOI: 10.1371/journal.pone.0216799
PMC ID: 6516678
PubMed ID: 31086415
SO-VID: 2b2e7113-68b7-42a1-8a88-6ce21154c915
Copyright © © 2019 Chiang et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by: Chung Shan Medical University and Chi-Mei Medical Center cooperative project
Award ID: CSMU-CMMC-106-02 and CMCSMU10602
Award Recipient
:
ORCID: http://orcid.org/0000-0003-0140-9943
Bor-Show Tzang
Funded by: funder-id http://dx.doi.org/10.13039/501100004663, Ministry of Science and Technology, Taiwan;
Award ID: MOST-106-2314-B040-023
Award Recipient
:
Tsai-Ching Hsu
Funded by: Ministry of Science and Technology, Taiwan (TW)
Award ID: 107-2314-B040-004
Award Recipient
:
Tsai-Ching Hsu
This study was supported by the Chung Shan Medical University and Chi-Mei Medical
Center cooperative project under Grant [CSMU-CMMC-106-021; CMCSMU106021]; and Ministry
of Science and Technology under Grant [MOST-106-2314-B040-023 and 107-2314-B040-004],
Taiwan. The funders had no role in study design, data collection and analysis, decision
to publish, or preparation of the manuscript.
Subject:
Research Article
Subject:
Research and Analysis Methods
Subject:
Animal Studies
Subject:
Experimental Organism Systems
Subject:
Model Organisms
Subject:
Mouse Models
Subject:
Research and Analysis Methods
Subject:
Model Organisms
Subject:
Mouse Models
Subject:
Research and Analysis Methods
Subject:
Animal Studies
Subject:
Experimental Organism Systems
Subject:
Animal Models
Subject:
Mouse Models
Subject:
Medicine and Health Sciences
Subject:
Pulmonology
Subject:
Asthma
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Recombinant Proteins
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Blood Cells
Subject:
White Blood Cells
Subject:
Lymphocytes
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
Lymphocytes
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
Lymphocytes
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
Lymphocytes
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Immune Physiology
Subject:
Cytokines
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Immune Physiology
Subject:
Cytokines
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune System
Subject:
Innate Immune System
Subject:
Cytokines
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune System
Subject:
Innate Immune System
Subject:
Cytokines
Subject:
Biology and Life Sciences
Subject:
Developmental Biology
Subject:
Molecular Development
Subject:
Cytokines
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune Response
Subject:
Inflammation
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune Response
Subject:
Inflammation
Subject:
Medicine and Health Sciences
Subject:
Diagnostic Medicine
Subject:
Signs and Symptoms
Subject:
Inflammation
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Signs and Symptoms
Subject:
Inflammation
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
DNA viruses
Subject:
Parvoviruses
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Medical Microbiology
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Parvoviruses
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Pathogens
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Parvoviruses
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral Pathogens
Subject:
Parvoviruses
Subject:
Research and Analysis Methods
Subject:
Immunologic Techniques
Subject:
Immunoassays
Subject:
Enzyme-Linked Immunoassays
