Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase

Lin, Herbert Y.; Ng-Eaton, Elinor; Weinberg, Robert A.; Lodish, Harvey F.; Wang, Xiao-Fan

doi:10.1016/0092-8674(92)90152-3

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Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase

Author(s): Herbert Y. Lin , Xiao-Fan Wang , Elinor Ng-Eaton , Robert A. Weinberg , Harvey F. Lodish

Publication date Created: February 1992

Publication date (Print): February 1992

Journal: Cell

Publisher: Elsevier BV

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The University of Wisconsin Genetics Computer Group (UWGCG) has been organized to develop computational tools for the analysis and publication of biological sequence data. A group of programs that will interact with each other has been developed for the Digital Equipment Corporation VAX computer using the VMS operating system. The programs available and the conditions for transfer are described.

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Signal transduction by receptors with tyrosine kinase activity.

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A new method for identifying secretory signal sequences and for predicting the site of cleavage between a signal sequence and the mature exported protein is described. The predictive accuracy is estimated to be around 75-80% for both prokaryotic and eukaryotic proteins.