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      Effect of Supernatants Derived from T Lymphocyte Culture in Minimal Change Nephrotic Syndrome on Rat Kidney Capillaries

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          Abstract

          The effect on the kidney capillaries of T lymphocyte culture supernatants from patients with minimal change nephrotic syndrome was studied by infusion into the left renal artery of rats. The supernatants of T lymphocyte cultures from nephrotic patients induced significant proteinuria and a reduction of anionic sites in the glomerular basement membrane of the kidneys in the rats. These changes were not produced in rats receiving equivalent supernatants from healthy controls.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1989
          1989
          09 December 2008
          : 51
          : 1
          : 73-76
          Affiliations
          aDepartment of Pediatrics, bSecond Department of Pathology and cDepartment of Clinical Pathology, Gunma University School of Medicine, Maebashi, Gunma, Japan
          Article
          185246 Nephron 1989;51:73–76
          10.1159/000185246
          2783765
          © 1989 S. Karger AG, Basel

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          Page count
          Pages: 4
          Categories
          Original Paper

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