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      Association Between Statin Use After Diagnosis of Esophageal Cancer and Survival: A Population-Based Cohort Study.

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          Abstract

          Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors), commonly prescribed in the primary and secondary prevention of cardiovascular disease, promote apoptosis and limit proliferation of esophageal cancer cell lines. We investigated whether statin use after a diagnosis of esophageal cancer is associated with reduced esophageal cancer-specific and all-cause mortality.

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          Author and article information

          Journal
          Gastroenterology
          Gastroenterology
          Elsevier BV
          1528-0012
          0016-5085
          Apr 2016
          : 150
          : 4
          Affiliations
          [1 ] Norwich Medical School, University of East Anglia, Norwich, United Kingdom; Department of Gastroenterology, Norfolk and Norwich University Hospital, Norwich, United Kingdom. Electronic address: Leo.Alexandre@uea.ac.uk.
          [2 ] Norwich Medical School, University of East Anglia, Norwich, United Kingdom.
          [3 ] Department of Gastroenterology, Norfolk and Norwich University Hospital, Norwich, United Kingdom.
          [4 ] Norwich Medical School, University of East Anglia, Norwich, United Kingdom; Department of Gastroenterology, Norfolk and Norwich University Hospital, Norwich, United Kingdom.
          Article
          S0016-5085(16)00003-2
          10.1053/j.gastro.2015.12.039
          26775632
          2b393668-57f3-44a9-bcea-bd0d73c5440f
          History

          HMG-CoA,CPRD,Esophagus,Pleiotropy
          HMG-CoA, CPRD, Esophagus, Pleiotropy

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