+1 Recommend
1 collections
      • Record: found
      • Abstract: found
      • Article: found

      Sex Differences in Cholinergic Enzymes of Diagonal Band Nuclei in the Rat Preoptic Area



      S. Karger AG

      Preoptic area, Choline acetylase, Acetylcholine esterase, Gonadal hormones

      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          Activities of choline acetylase (CAT), synthetic enzyme for acetylcholine, and acetylcholine esterase (AChE), degradative enzyme for acetylcholine, were measured in preoptic nuclei of gonadectomized, estradiol-treated male and female rats. Estradiol-dependent enzymatic changes were localized within discrete POA nuclei and both the location and direction of the changes were dependent on the sex of the rat. Estradiol administration increased CAT and AChE activity in the nucleus of the horizontal limb of the diagonal band in ovariectomized (OVX) females but not castrate (CAS) males and decreased CAT activity in the nucleus of the vertical limb of the diagonal band in CAS males but not OVX females. Activity of AChE was increased by estradiol administration in the bed nucleus of the stria terminalis in OVX females but not in CAS males. Activity of cholinergic enzymes remained higher in the nucleus of the horizontal limb of the diagonal band of females than males after long-term gonadectomy. Estradiol-dependent increased CAT activity in the nucleus of the horizontal limb of the diagonal bands of OVX females was partially blocked by administration of the protein synthesis inhibitor, anisomycin, and was not affected by acute progesterone administration. These results extend previous morphological demonstrations of dimorphisms between the sexes within the preoptic area to include neurochemical parameters of neuronal function.

          Related collections

          Author and article information

          S. Karger AG
          26 March 2008
          : 36
          : 6
          : 475-482
          Rockefeller University, New York, N.Y., USA
          123501 Neuroendocrinology 1983;36:475–482
          © 1983 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 8
          Original Paper


          Comment on this article